CYTOTOXICITY ACTIVITY OF SOME INDIAN MEDICINAL PLANTS


Dora Babu Neerugatti, Ganga Rao Battu, Raviteja Bandla

Abstract


Objective: The current study is carried out to evaluate cytotoxicity activity of the methanolic extracts of some medicinal plants (Buchanania axillaris Desr, Tamilnadia ulignosa Retz, Phaseolus semierectus L and Stylosanthes fruticosa Retz).

Methods: Cytotoxicity activity was evaluated on human cancer cell lines such as lung cancer (A549) and skin cancer (A431) using MTT assay method.

Results: The selected plant extracts showed the dose-dependent cytotoxicity activity on the tested cell lines. The cytotoxicity variations on different cell lines were also observed for tested plants extracts. The cytotoxicity of the extracts was increased as the concentration of them was increased. Among all tested plants extracts Phaseolus semierectus showed the better cytotoxicity activity on tested cell lines.

Conclusion: The results of the present study supported the folkloric usage of the studied plants and confirmed that the plant's extracts have the bioactive constituents with cytotoxic properties and their isolation can be useful for developing new anticancer drugs.


Keywords


Cytotoxicity, Lung cancer, Skin cancer, Cell lines and MTT assay

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About this article

Title

CYTOTOXICITY ACTIVITY OF SOME INDIAN MEDICINAL PLANTS

Keywords

Cytotoxicity, Lung cancer, Skin cancer, Cell lines and MTT assay

DOI

10.22159/ijcpr.2016v8i4.15687

Date

18-10-2016

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 8, Issue 4, 2016 Page: 86-88

Online ISSN

0975-7066

Statistics

17 Views | 34 Downloads

Authors & Affiliations

Dora Babu Neerugatti
Department of Pharmacognosy and Phytochemistry, Santhiram College of Pharmacy, Nandyal, Kurnool, Andhra Pradesh, India 518502

Ganga Rao Battu
Pharmacognosy and Phytochemistry, Andhra University, Visakhapatnam Andhra Pradesh 530003

Raviteja Bandla
Pharmaceutical Chemistry Department, MAM College of Pharmacy, Narasaraopet, Andhra Pradesh, India 522601


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