DEVELOPMENT OF EXTRACTIVE SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF IRON (III) WITH SCHIFF BASE 2-[(2-HYDROXYPHENYLIMINO) METHYL]-4-NITROPHENOL

  • Datta B. Mandhare V. E. S. College of Art, Science and Commerce, Sindhi Society Chembur, Mumbai 400071, India
  • Vasant D. Barhate V. E. S. College of Art, Science and Commerce, Sindhi Society Chembur, Mumbai 400071, India

Abstract

Objective: A simple spectrophotometric method has been developed for the determination of Iron (III) by using Schiff base 2-[(2-hydroxyphenylimino) methyl]-4-nitrophenol [HPIMNP].

Methods: HPIMNP extracts Fe (III) quantitatively (99.95%) into chloroform from an aqueous solution of pH range 4.0-6.0.

Results: The chloroform extracts show maximum absorption at 510 nm (λ max). Beer’s Law is obeyed over the Fe (III) concentration range of 0.5 to 20.0 µg/ml. The Molar absorptivity and Sandell’s sensitivity for Fe–HPIMNP system is 5000 L mol ˉ1 cmˉ1 and 0.011 µg cmˉ2respectively. The composition of extracted species is found to be 1: 3 [Fe-HPIMNP] by Job’s continuous variation and Mole-ratio method. Interference by various ions has been studied.

Conclusion: The proposed method is rapid, sensitive, reproducible and accurate and it has been satisfactory applied for the determination of Iron in Pharmaceutical Samples.

Keywords: Solvent Extraction, Extractive Spectrophotometry, Iron (III), Schiff base, 2-[(2-hydroxyphenylimino) methyl]-4-nitrophenol [HPIMNP], Pharmaceutical sample.

References

1. Feig F. “Chemistry of specific, selective and sensitive reactions”. English Ed. By. Oesper RE, New York: Academic press; 1949. p. 209-10.
2. Nath R, Nautiyal SC, Singh H. Determination of metal ions with organic reagent part1-studies on some nitro substituted ortho hydroxy ketoximes. Labdev J Sci Technol Part A: Phys Sci 1974;12A(2):53-8.
3. Scott WW. “Standard methods of chemical Analysis”. Von nostrand company, Inc; 1939. p. 182.
4. Fasina TM, Ejiah FN, Dueke-Eze CU, Idika N. Synthesis and antimicrobial activity of Schiff bases derived from substituted salicylaldehyde with 2-aminophenol and 2-aminothiophenol. J Sci Res Dev 2013;14:95-8.
5. Vogel AI. “Practical organic chemistry.” 5th Ed. London: Longman group limited; 1989.
6. Vogel AI. “Textbook of Quantitative inorganic analysis”. 4th Ed. London: Longman group limited; 1978.
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Mandhare, D. B., and V. D. Barhate. “DEVELOPMENT OF EXTRACTIVE SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF IRON (III) WITH SCHIFF BASE 2-[(2-HYDROXYPHENYLIMINO) METHYL]-4-NITROPHENOL”. International Journal of Current Pharmaceutical Research, Vol. 8, no. 4, 1, pp. 89-91, doi:10.22159/ijcpr.2016v8i4.15924.
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