FAST DISSOLVING TABLETS: A REVIEW


Ashish Masih, Amar Kumar, Shivam Singh, Ajay Kumar Tiwari

Abstract


Fast dissolving tablets emerge as one of the popular and widely accepted dosage forms, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various drugs have limitations like first-pass metabolism, psychiatric patients, bedridden and uncooperative patients. FDTs are disintegrating or dissolve quickly in the saliva without a need of water. Fast dissolving tablets are designed to dissolve in saliva remarkably faster, within a few seconds (less than 60 seconds), and those are real fast-dissolving tablets. FDTs formulations contain super disintegrants to enhance the disintegration rate of a tablet in the buccal cavity. FDTs have advantages such as easy portability and manufacturing, accurate dosing, good chemical and physical stability and an ideal alternative for geriatric and pediatric patients. FDTs have disintegrated quickly, absorb faster so, in vitro drug release time improve and this property of drugs (dosage form) enhanced bioavailability. FDT formulations have the advantage of both conventional tablet formulation and liquid dosage form. There are several technologies that are conventional or patented based on spray drying, cotton candy process, sublimation, melt granulation, direct compression freezes drying/lyophilization, phase transition process, mass extrusion, etc. have been developed for manufacturing of FDTs. In this review contain brief information about FDTs including definition, advantages, needs or requirements of FDTs, salient features of FDTs, limitations, challenges to developing FDT, marketed formulations of fast dissolving tablets, etc.


Keywords


Fast dissolving tablets, FDTs, Superdisintegrants, Mouth dissolving tablets, MDTs

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References


Hannan PA, Khan JA, Khan A, Safiullah S. Oral dispersible system: a new approach in drug delivery syste. Indian J Pharm Sci 2016;78:2-7.

Bhowmik D, Chiranjib B, Krishnakanth, Pankaj, Chandira RM. Fast dissolving tablet: an overview. J Chem Pharm Res 2009;1:163-77.

Siddiqui N, Garg G, Sharma PK. Fast dissolving tablets: preparation, characterization and evaluation: an overview. Int J Pharm Sci Rev Res 2010;2:87-96.

Gupta DK, Bajpai M, Chatterjee DP. Fast mouth is dissolving disintegrating tablet and patient counselling points for FDDTS-a review. Int J Res Dev Pharm L Sci 2014;3:949-58.

Nautiyal U, Singh S, Singh R, Gopal, Kakar S. Fast dissolving tablets as a novel boon: a review. J Pharm Chem Biol Sci 2014;2:5-26.

Kaur T, Gill B, Kumar S, Gupta GD. Mouth dissolving tablets: a novel approach to drug delivery. Int J Curr Pharm Res 2011;1:1-7.

Patel TS, Sengupta M. Fast dissolving tablet technology. World J Pharm Sci 2013;2:485-508.

Ashish P, Harsoliya MS, Pathan JK, Shruti S. A review: formulation of mouth dissolving tablet. Int J Pharm Res 2011;1:1-8.

Sharma R, Rajput M, Prakash M, Sharma S. Fast dissolving drug delivery system. Int Res J Pharm 2011;2:21-9.

Pagar R, Ahirrao S, Yallatikar T, Wagh M. Review on orodispersible tablets. Int J Res Dev Pharm L Sci 2014;3:949-58.

Mishra US, Prajapati SK, Bhardwaj P. A review on formulation and evaluation for mouth dissolving tablet. World J Pharm Pharm Sci 2014;8:1778-810.

Kuchekar BS, Badha AC, Mahajan HS. Mouth dissolving tablets: a novel drug delivery system. Pharmatimes 2003;35:7-9.

Sharma S. New generation of the tablet: fast dissolving tablet. Latest Rev Pharmainfo Net; 2008. p. 6.

Kumari S, Visht S, Sharma PK, Yadav RK. Fast dissolving drug delivery system: a review article. J Pharm Res 2010;3:1444-9.

Mohanachandran PS, Sindhumol PG, Kiran TS. Superdisintegrants: an overview. Int J Pharm Sci Rev Res 2011;6:105-9.

Deshmukh VN. Mouth dissolving drug delivery system: a review. Int J Pharm Tech Res 2012;4:412-21.

Kumaresan C. Orally disintegrating tablet-mouth dissolving, sweet taste and target release profile. Pharm Rev 2008;6:1.

Parkash V, Maan S, Deepika, Yadav SK, Hemlata, Jogpal V. Fast disintegrating tablets: opportunity in drug delivery system. J Adv Pharm Technol Res 2011;2:223-35.

Nagar P, Singh K, Chauhan I, Verma M, Yasir M, Khan A. Orally disintegrating tablets: formulation, preparation techniques and evaluation. J Appl Pharm Sci 2011;4:35-45.

Velmurugan S, Vinushitha S. Oral disintegrating tablets: an overview. Int J Chem Pharm Sci 2010;1:1-12.

Sri KV, Raj GB, Ravishanker D, Kumar CA. Preparation and evaluation of montelukast oral dispersible tablets by direct compression method. Int Res J Pharm 2012;7:315-8.

Yang D, Kulkarni R, Behme RJ, Kotiyan PN. Effect of the melt granulation technique on the dissolution characteristics of griseofulvin. Int J Pharm 2007;329:72-80.

Khan AB, Tripuraneni A. Fast dissolving tablets–a novel approach in drug delivery. Rguhs J Pharm Sci 2014;1:7-16.

Chowdary YA, Soumya M, Madhubabu M, Aparna K, Himabindu P. A review on fast dissolving drug delivery systems-A pioneering drug delivery technology. BEPLS 2012;1:8-20.

Abdulraheman ZS, Patel MR, Patel KR. A review on immediate release tablet. Int J Univers Pharm Bio Sci 2014;3:93-113.

Patel P, Dhanani C, Kadeval A, Patel M, Patel N‚ Patel R. A modern approach on fast dissolving tablets. Int J Modern Pharm Res 2012;1:1-17.

Shukla D, Chakraborty S, Singh S, Mishra B. An overview of formulation of mouth dissolving tablets. Sci Pharm 2009;77:309-26.

Hirani JJ, Rathod DA, Vadalia KR. A review in orally disintegrating tablets. Tropical J Pharm Res 2009;8:161-72.

Menat AK, Patel MS, Patel MR, Patel NM. Fast dissolving tablets a novel approach to drug delivery. Asian J Pharm Sci Res 2012;2:13-21.

Keshari R, Bharkatiya M, Rathore KS, Shyama S, Kumar, Sirvi G, somani N, et al. Fast disolving tablet drug delivery system-an overview. Int J Pharm 2015;5:577-89.

Acosta C, Tabare R, Ouali A. US patent; 1998;5:807.

Gohel M, Patel M, Amin A, Agrawal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique. AAPS PharmSciTech 2004;5:36.

Mohan SC, Margret CR. Recent advances in orodispersible tablets: a review. Int J Drug Discovery Herbal Res 2011; 2:78-83.

Yourong F, Yang S, Jeong SH, Kimura S, Park K. Orally fast disintegrating tablets: developments, technologies, taste-masking and clinical studies. Crit Rev Ther Drug Carrier Syst 2004;21:433–75.

Jeong SH, Fu Y, Park K. Frosta: a new technology for making fast-melting tablets. Expert Opin Drug Delivery 2005;2:1107-16.

Sreenivas SA, Dandagi PM, Gadad AP, Godbole AM, Hiremath SP, Mastiholimath VSM, et al. Orodispersible tablets: new fangled drug delivery system: a review. Indian J Pharm Educ Res 2005;39:177-81.

Seager H. Drug-deliver products and the zydis, fast-dissolving dosage. J Pharm Pharmacol 1998;50:375-82.

Takagi H, Kajiyama A, Yanagisawa M. Rapidly disintegrable pharmaceutical composition. U. S. Patent; 2005;6:899.

Divate S., Kunchu K, Sockan GN. Fast disintegrating tablets–an emerging trend. Int J Pharm Sci Rev Res 2011;2:18-22.

Asija R, Asija S, Gupta A, Hemlata A. A review on fast dissolving drug delivery system. Int J Res Pharm Sci 2014;4:7-12.




About this article

Title

FAST DISSOLVING TABLETS: A REVIEW

Keywords

Fast dissolving tablets, FDTs, Superdisintegrants, Mouth dissolving tablets, MDTs

DOI

10.22159/ijcpr.2017v9i2.17382

Date

01-03-2017

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 2, 2017 Page: 8-18

Online ISSN

0975-7066

Statistics

253 Views | 883 Downloads

Authors & Affiliations

Ashish Masih

Amar Kumar

Shivam Singh
School of Pharmaceutical Science, Jaipur National University, Jagatpura, Jaipur, Rajasthan

Ajay Kumar Tiwari


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