PRELIMINARY PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTI-DIARRHOEAL ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF CLERODENDRUM INFORTUNATUM


Animesh Hazarika, Dipankar Saha

Abstract


Objective: To determine preliminary phytochemical Screening and evaluation of Antidiarrheal activity of ethanolic extract of Leaves Clerodendrum infortunatum.

Methods: The ethanolic extract of leaves of Clerodendrum infortunatum was prepared and analyzed for phytochemical constituents using standard method and evaluate scientifically the anti-diarrheal effect using leaves of Clerodendrum infortunatum by castor oil-inducing method. Animals were divided into four groups. Group-I was treated with distilled water 2 ml/kg body weight. Group-II was treated with loperamide 1 mg/kg body weight, Group-III and Group-IV were treated with ethanolic extract of leaves Clerodendrum infortunatum 200 mg/kg and 500 mg/kg body weight respectively.

Results: Various phytochemical analysis revealed the presence of sterols, terpenoids, alkaloids, carbohydrates, tannins, glycoside, saponins, proteins and amino acids. The ethanolic extract of Clerodendrum infortunatum leaves given by oral route to mice at doses of 200 mg/kg and 500 mg/kg significantly showed antidiarrheal activity against castor oil induced diarrhea as compared with control group and standard.

Conclusion: The present study concluded that ethanolic extract of leaves of Clerodendrum infortunatum contain the high presence of phytochemical components and it showed that the leaves of Clerodendrum infortunatum having significant antidiarrheal activity. All doses of the plant extracts showed a significant delay in castor oil-induced diarrhea and this justifies the use of this plant as a herbal remedy against diarrhea.

 


Keywords


Anti-diarrheal, Clerodendrum infortunatum, Castor oil, Loperamide

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About this article

Title

PRELIMINARY PHYTOCHEMICAL SCREENING AND EVALUATION OF ANTI-DIARRHOEAL ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF CLERODENDRUM INFORTUNATUM

Keywords

Anti-diarrheal, Clerodendrum infortunatum, Castor oil, Loperamide

DOI

10.22159/ijcpr.2017v9i4.20980

Date

14-07-2017

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 9, Issue 4, 2017 Page: 143-146

Online ISSN

0975-7066

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90 Views | 98 Downloads

Authors & Affiliations

Animesh Hazarika
Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Hatkhowapara, Guwahati-17

Dipankar Saha
Depertment of Pharmacology, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Hatkhowapara, Guwahati-17


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