FORMULATION AND EVALUATION OF NANOSUSPENSION OF VALSARTAN


Manishaanjane ., Shikha Agrawal, Amreen Khan

Abstract


Objective: The objective of the present research work was to formulate and evaluate Valsartan nanosuspension by nanoprecipitation ultra sonication method using different polymers to enhance solubility and bioavailability of the poorly water-soluble drug.

Methods: Formulation of nanosuspension of valsartan by nanoprecipitation technique was used. The nanosuspension formulations were prepared using different polymers such as hydroxyl propyl methyl cellulose E50, polyvinyl pyrollidone k-30, polyethene glycol 6000 and sodium lauryl sulphate was used as the surfactant.

Results: The formulation of nanosuspension was formed clear and no sedimentation was seen on further shaking. The nanosuspension formulations were Valsatan shows maximum solubility in HPMC as a non-volatile solvent. All the Preformulation parameters were evaluated such as organoleptic characterization of drug sample, melting point, pH, partition coefficient, identification of drug samples by using UV spectroscopy and FTIR analytical method, preparation of calibration curves, solubility studies of drug sample like qualitative, quantitative and pH dependent solubility of drug in different pH buffer solution. The viscosity of the dispersion medium was more in F10.895 mPa-s and F2 0.894 mPa-s than the other formulations. The particle size distribution of the nanosuspension with zeta potential found to be negative mv. Fourier transform infrared spectroscopy indicated that there was no possible interaction between drug and polymer.

Conclusion: From this study, it was concluded that in recent advances in novel drug delivery system aims to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for administration and to achieve better patient compliance, one such approach is nanosuspension.


Keywords


Nanosuspension, Ultrasonocation, Nanoprecipitation, Solubility, Valsartan, Antihypertensive

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About this article

Title

FORMULATION AND EVALUATION OF NANOSUSPENSION OF VALSARTAN

Keywords

Nanosuspension, Ultrasonocation, Nanoprecipitation, Solubility, Valsartan, Antihypertensive

DOI

10.22159/ijcpr.2018v10i2.25874

Date

15-03-2018

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 10, Issue 2 (Mar-Apr), 2018 Page: 68-74

Online ISSN

0975-7066

Authors & Affiliations

Manishaanjane .
Department of Pharmaceutics, Swami Vivekanand College of Pharmacy, Indore 452020, Madhya Pradesh, India

Shikha Agrawal

Amreen Khan


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