USE OF ALUMINA IN PREPARATION OF OXIME: A PRECURSOR FOR BECKMANN REARRANGEMENT


Sourav Sarkar, Pulak Gangopadhyay

Abstract


Oxime is an important precursor for many reactions like Beckmann rearrangement, oxime ether preparation etc. Oxime is generally prepared in strong acidic [1], strong basic [2] medium. Even some methods involving mild basic medium [3]is also known. But these procedures involve hazardous chemicals like inorganic acid, inorganic base, organic bases like Pyridine[4], Hyamine[5] etc. Some green methodologies have been also developed but that also involve expensive reagents like Bi2O3[6] etc. Here in we report the preparation of oxime in a mild basic medium. Alumina (Al2O3) is pretty cheap and not mentionable hazardous and it has been used here for the first time in synthesis of oxime.

Keywords: Alumina, Beckmann Rearrangement, Column Chromatography, Ethanol, Hydroxylamine Hydrochloride, Oxime, Thin Layer Chromatography

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References


Oxime is an important precursor for many reactions like Beckmann rearrangement, oxime ether preparation etc. Oxime is generally prepared in strong acidic [1], strong basic [2] medium. Even some methods involving mild basic medium [3] is also known. But these procedures involve hazardous chemicals like inorganic acid, inorganic base, organic bases like Pyridine [4], Hyamine [5] etc. Some green methodologies have been also developed but that also involve expensive reagents like Bi2O3 [6] etc. Here in we report the preparation of oxime in a mild basic medium. Alumina (Al2O3) is pretty cheap and not mentionable hazardous and it has been used here for the first time in synthesis of oxime.

Keywords: Alumina, Beckmann Rearrangement, Column Chromatography, Ethanol, Hydroxylamine Hydrochloride, Oxime, Thin Layer Chromatography




About this article

Title

USE OF ALUMINA IN PREPARATION OF OXIME: A PRECURSOR FOR BECKMANN REARRANGEMENT

Date

07-10-2014

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 6, Issue 4 (Oct-Dec 2014) Page: 1-2

Online ISSN

0975-7066

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314 Views | 308 Downloads

Authors & Affiliations

Sourav Sarkar

Pulak Gangopadhyay


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