SPECTROPHOTOMETRIC DETERMINATION OF DASATINIB IN PHARMACEUTICAL FORMULATIONS

  • YOGESH THORAT D. S. T. S. Mandal’s College of Pharmacy, Solapur 413004. Maharashtra, India
  • ANITA SHEGAONKAR D. S. T. S. Mandal’s College of Pharmacy, Solapur 413004. Maharashtra, India
  • SMITA KUMBHAR D. S. T. S. Mandal’s College of Pharmacy, Solapur 413004. Maharashtra, India
  • VINOD MATOLE D. S. T. S. Mandal’s College of Pharmacy, Solapur 413004. Maharashtra, India
  • AVINASH HOSMANI Government College of Pharmacy, Ratnagiri

Abstract

Objective: A new, simple, sensitive, precise and reproducible bioanalytical method was developed for the determination of Dasatinib in pharmaceutical formulations with Chloranilic acid.


Methods: The method is based on formation of violet colored complex. The UV spectrum of Dasatinib in methanol showed λ max at 521 nm. Beer’s law is valid in the concentration range of 10-60 μg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness.


Results: The method has demonstrated excellent linearity over the range of 10-60 μg/ml with regression equation y = 0.021x-0.083 and regression correlation coefficient r2= 0.997. Moreover, the method was found to be highly sensitive with LOD (2.96μg/ml) and LOQ (8.98μg/ml).


Conclusion: Based on results the proposed method can be successfully applied for the assay of Dasatinib in various pharmaceutical dosageforms.

Keywords: Dasatinib, Bioanalytical method, Spectrophotometry, Chloranilic acid, Method development, Validation

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THORAT, Y., A. SHEGAONKAR, S. KUMBHAR, V. MATOLE, and A. HOSMANI. “SPECTROPHOTOMETRIC DETERMINATION OF DASATINIB IN PHARMACEUTICAL FORMULATIONS”. International Journal of Current Pharmaceutical Research, Vol. 12, no. 2, Mar. 2020, pp. 68-71, doi:10.22159/ijcpr.2020v12i2.37492.
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