UV VISIBLE SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF DASATINIB IN BULK AND SOLID DOSAGE FORM

  • SAILI MADUR D. S. T. S Mandal’s College of Pharmacy, Solapur 413004, Maharashtra, India
  • VINOD MATOLE D. S. T. S Mandal’s College of Pharmacy, Solapur 413004, Maharashtra, India
  • MALLINATH KALSHETTI D. S. T. S Mandal’s College of Pharmacy, Solapur 413004, Maharashtra, India

Abstract

Objective: A new, simple, sensitive, precise, reproducible UV visible spectrophotometric method was developed for the determination of Dasatinib in Tablet dosage form with­­­ methanol.


Methods: The method is based on the formation of a colorlesscomplex. The UV spectrum of Dasatinib in methanol showed maximum wavelength at 248 nm. Beer’s law is valid in the concentration range of 7-35µg/ml. this method was validated for linearity, accuracy, precision, assay, ruggedness and robustness.


Results: The method has demonstrated excellent linearity over the range of 7-35µg/ml with the regression equation y = 0.0332x+0.0633 and regression coefficient i.e. r2= 0.9994moreover, the method was found to be highly sensitive with LOD(1.08µg/ml) and LOQ(3.29µg/ml).


Conclusion: Based on the results the proposed method can be successfully applied for the assay of Dasatinib in various tablet dosage forms.

Keywords: Dasatinib, UV visible spectrophotometer, Methanol, Method development and validation

References

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MADUR, S., V. MATOLE, and M. KALSHETTI. “UV VISIBLE SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF DASATINIB IN BULK AND SOLID DOSAGE FORM”. International Journal of Current Pharmaceutical Research, Vol. 12, no. 4, July 2020, pp. 90-93, doi:10.22159/ijcpr.2020v12i4.39089.
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