• Jessy Shaji Dept. of Pharmaceutics, Prin. K. M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai 400005, India
  • Sharvari Garude Dept. of Pharmaceutics, Prin. K. M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai 400005, India


Ketorolac tromethamine, Transdermal delivery, Transethosomes, ethosomes, Permeation studies


The aim of this investigation was to formulate, evaluate and compare the transdermal potential of novel vesicular carriers: transethosomes and ethosomes. Transethosomes (TELs) and ethosomes (Els) were prepared by cold method and were characterized for particle size, entrapment efficiency, transmission electron microscopy (TEM), zeta potential, elasticity measurement, in-vitro drug release, ex-vivo permeation studies and in-vivo study. Transethosomal and ethosomal formulation showed particle size of 180 ± 70 nm and134 ± 65 nm. Transethosomes showed higher drug entrapment (80.08 ± 4.5%) than ethosomes (70.79 ± 5.6%). Both the formulation showed good zeta potential indicating good stability. The elasticity of transethosomal vesicles was found to be 3-fold higher than the ethosomal vesicles. The transdermal flux of transethosomal gel was 47.43± 0.2 µg/cm2/h and was found to give 3 fold increase in release as compared to ethosomal gel which gave 2 fold higher release of 40.38 ± 2.50µg/cm2/h as compared to the hydroethanolic solution with a release of 17.333± 0.15µg/cm2/h. Hence, the results suggested transethosomes to be a more efficient carrier system as compared to ethosomes for transdermal delivery of ketorolac tromethamine.


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How to Cite

Shaji, J., and S. Garude. “TRANSETHOSOMES AND ETHOSOMES FOR ENHANCED TRANSDERMAL DELIVERY OF KETOROLAC TROMETHAMINE: A COMPARATIVE ASSESSMENT”. International Journal of Current Pharmaceutical Research, vol. 6, no. 4, Oct. 2014, pp. 88-93,



Original Article(s)