FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF DONEPEZIL HYDROCHLORIDE
Objective: The present study was aimed to develop the formulation and in vitro evaluation of Orodispersible tablets by wet granulation method using Donepezil HCl as a model drug to enhance patient compliance.
Methods: In the wet granulation method, a mixture of microcrystalline cellulose and hydroxypropyl methylcellulose were used along with superdisintegrants, i.e., croscarmellose sodium and crospovidone. The prepared granules were subjected to both pre and post-compression evaluation parameters including; FTIR spectroscopy, micromeritics properties, tablet weight variation, hardness, friability, drug content, disintegration time and in vitro drug release.
Results: FTIR studies indicated that there was nointeraction between the drug and the excipients used. The formulation containing high concentration of crospovidone and mixture as the best formulation F2 based on in vitro drug release characteristics of tablet formulation.
Conclusion: The results of this work suggested that orodispersible tablets of Donepezil hydrochloride with rapid disintegration time, fast drug release and good hardness can be efficiently and successfully formulated by wet granulation method.
2. Chang RK, Guo X, Burnside BA, Cough RA. Fast dissolving tablets. PharmTech 2000;24:52–8.
3. Dobetti L. Fast-melting tablets: developments and technologies. PharmaTech. 2001;9 Suppl:44–50.
4. Kuchekar BS, Arumugam V. Fast dissolving tablets. Indian J Pharm Edu 2001;35:150–2.
5. Barner EL, Grey SL. Donepezilusein alzheimer disease. Ann. Pharmacother 1998,32:70-2.
6. The Merck Index. 14th edn. USA: Merck and Co, Inc; 2006. p. 578.
7. Sugimoto H, Ogura H, Arai Y. Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor. Japan J Pharm 2002;89:7-20.
8. Pathra CHN, Bhanoji Rao MK, Yadav KS, Prakash K. In?uence of some cellulose ethers on the release of propranolol hydrochloride from guar gum matrix tablets. Ind J Pharm Sci 2004;66:636–41.
9. Kaushik D, Dureja H, Saini TR. Formulation and evaluation of olanzapine mouth dissolving tablets by effervescent formulation approach. Indian Drugs 2004;41:410–2.
10. Bi YX, Sunada H, Yonezawa Y, Danjo K. Evaluation of rapidly disintegrating tablets by direct compression method. Drug Dev Ind Pharm 1999;25:571–81.
11. Indian Pharmacopoiea. New Delhi: Controller of Publications; 1996. p. 735–6.
12. Bhagwati ST, Hiremath SN, Sreenivas SA. Comparative evaluation of disintegrants by formulating ce?xime dispersible tablets. Indian J Pharm Edu Res 2005;39:194–7.
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