INVESTIGATION OF ANTHELMINTIC EFFECT OF NEOLAMARCKIA CADAMBA FRUIT EXTRACTS IN ASCARIASIS
Keywords:Helminthiasis, Neolamarckia cadamba, Anthelmintic activity, Extracts, Ascariasis
Objective: Investigation of Anthelmintic effect of Neolamarckia Cadamba fruit extracts (Ethanol, Aquaous, Phenyl ether, Chloroform) in Ascariasis.
Methods: The experiment was conducted on an adult Indian earthworm, Eiseniafoetida, owing of its morphological and physiological similarities to the human intestine roundworm parasite. Six sets of six earthworms were discharged sequentially into different extracts of N. cadamba fruits at dose levels of 5,10,15,20, and 25 mg/ml, respectively, and 25 mg/ml of albendazole solutions. Albendazole was employed as the standard reference medication.
Results: The results showed that Ethanolic extract has the greatest degree of activity. When compared to any other extract or conventional medicine, it produces a paralytic effect sooner and has a shorter time to death (Albendazole). An ethanol extract included alkaloid, saponin, tannins, flavonoids, proteins, and amino acids. As a result, it is possible to infer that the ethenolic fruit extract of Neolomarckia Cadamba showed much more anthelmintic activity against Indian earthworms than the usual treatment (Albendazole).
Conclusion: The solvents Ethanol, Chloroform, Phenyl Ether, and Aquaous were used to extract the Neolamarckia Cadamba. The results showed that Ethanolic extract has the greatest degree of activity. When compared to any other extract or conventional medicine, it produces a paralytic effect sooner and has a shorter time to death (Albendazole).
Haque Rashidul. Human intestinal parasites. J Health Popul Nutr. 2007;25(4):387-91.
Fahim SM, Das S, Gazi MA, Mahfuz M, Ahmed T. Association of intestinal pathogens with faecal markers of environmental enteric dysfunction among slum-dwelling children in the first 2 years of life in Bangladesh. Trop Med Int Health. 2018 Nov;23(11):1242-50. doi: 10.1111/tmi.13141, PMID 30133067.
Weatherhead JE, Hotez PJ. Worm infections in children. Pediatr Rev. 2015 Aug;36(8):341-52; quiz 353-4. doi: 10.1542/pir.36-8-341, PMID 26232464.
https://www.cdc.gov/parasites/ascariasis/index.html. [Last accessed on 01 Apr 2021]
Darlington CD, Anitha GFS. Ascaridial volvulus: an uncommon cause of ileal perforation. Iran J Med Sci. 2018;43(4):432-5. PMID 30046214.
Zakzuk J, Casadiego S, Mercado A, Alvis-Guzman N, Caraballo L. Ascaris lumbricoides infection induces both, reduction and increase of asthma symptoms in a rural community. Acta Trop. 2018 Nov;187:1-4. doi: 10.1016/j.actatropica.2018.07.016, PMID 30040946.
https://www.healthline.com/health/ascariasis#roundworm-lifecycle. [Last accessed on 01 Apr 2021]
Saurabh Sethi MD. MPH Written by health editorial team; 2019.
Dept of Medicine, Henry J. Carter specialty hospital and nursing facility, New York: USA; 1965.
https://web.stanford.edu/group/parasites/ParaSites2005/Ascaris/JLora_ParaSite.htm [Last accessed on 01 Apr 2021]
Prasad S, Bhattacharya IC. Chemical study of the bark of Anthocephalus indicus Rich. Ind J Pharmacol. 1960;22:172-4.
Shilpi M, Ashish M, Padmini S, Prabodh S. In vitro anthelmintic activity of enicostemma littorale blume Int. J. Pharm. Sci. Res. 2011;2(5):1193-6.
Thorn GW, Adams RD, Braunwald E, Isselbacher KJ, Petersdrof RG. Harrison’s principles of internal medicine. New York: Mcgraw-Hill Co.; 1977. p. 1088-9.
Vigar Z. Atlas of medical parasitology. 2nd ed. Singapore: Procter & Gamble Publishing House; 1984. p. 216-7.
The wealth of India. A dictionary of Indian raw materials and industrial products. New Delhi, India: NISCAIR press publishers; 1962. p. 305-8.
Patel D, Kumar V. pharmacognostical studies of neolamarckia cadamba (roxb.) Bosser leaf. Int J. Green Pharm. 2008;2(1):26-7. doi: 10.4103/0973-8258.39159
How to Cite
Copyright (c) 2021 KULDEEP KAUR, AJEET PAL SINGH, AMAR PAL SINGH
This work is licensed under a Creative Commons Attribution 4.0 International License.