FORMULATION AND EVALUATION OF ANTIFUNGAL CREAM OF CHLORPHENESIN
Keywords:Fungal infection, Chlorphenesin, Antifungal cream
Objective: The main aim of our research was to develop an Antifungal cream formulation consisting of Chlorphenesin for the treatment of Fungal infections. Topical route is the most suitable route for skin infections.
Methods: The development of topical drug delivery systems designed to have systemic effects appears to be beneficial for a number of drugs on account of several advantages over conventional dosage forms(or) routes of drug administration. An Antifungal cream formulation consisting of Chlorphenesin was prepared.
Results: The formulation was subjected to in vitro diffusion studies. Microbiological studies were performed to find out the safety of materials used in the formulation.
Conclusion: The developed cream consisting of Cholrphnesin was found to be safe and effective for the treatment of fungal infection.
Sweetman SC. Martindale: the complete drug reference. 33rd ed. London, UK: Pharmaceutical Press; 2002. p. 381.
The pharmaceutical codex. 11th ed. London, UK: Pharmaceutical Press; 1979. p. 181.
https://labtestsonline.org/conditions/fungal-infections. [Last accessed on 25 Aug 2021].
Lee CM, Maibach HI. Deep percutaneous penetration into muscles and joints. J Pharm Sci. 2006;95(7):1405-13. doi: 10.1002/jps.20666, PMID 16729269.
Lim EH, Kim HR, Park YO, Lee Y, Seo YJ, Kim CD, Lee JH, Im M. Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream. J Am Acad Dermatol. 2014 May 1;70(5):918-23. doi: 10.1016/j.jaad.2014.01.893, PMID 24655819.
Neubert RH. Potentials of new nanocarriers for dermal and transdermal drug delivery. Eur J Pharm Biopharm. 2011;77(1):1-2. doi: 10.1016/j.ejpb.2010.11.003. PMID 21111043.
Benson HA. Elastic liposomes for topical and transdermal drug delivery. Curr Drug Deliv. 2009;6(3):217-26. doi: 10.2174/156720109788680813, PMID 19604135.
Purushotham Rao K, Khaliq K, Kharat SS, Sagare P, Patil SK. Preparation and evaluation of o/w cream for skin psoriasis. Int J Pharm Biol Sci. 2010;1:3.
Ind Std, Specification for Hair Creams, ind std institution, Manak Bhvan, bahadur Shah Zafar Marg, New Dehli-110002. 1st ed; 1978. p. 11-2.
Herbert LA. Pharmaceutical dosage forms. Rheology of dispersed systems; 1998. p. 367-422.
Baudonnet L, Grossiord JL, Rodriguez F. Physicochemical characterization and in vitro release of salicylic acid from O/W emulsions prepared with Montanov 68: effect of formulation parameters. Drug Dev Ind Pharm. 2004;30(9):975-84. doi: 10.1081/ddc-200037251, PMID 15554222.
Kydonieus AF. Transdermal delivery of drugs. Vol. 1. CRC Press: Bocaraton; 1987. p. 168.
Patel J, Patel B, Banwait H, Parmar K, Patel M. Formulation and evaluation of topical aceclofenac gel using different gelling agent. Int J Drug Dev Res 2011;3:156-64.
Parmar RB, Baria AH, Faldu SD, Tank HM. Design and evaluation of poly-herbal formulation in semisolid dosage form for its antibacterial activity. J Pharm Res. 2009;2:1095-7.
More BH, Sakharwade SN, Tembhurne SV, Sakarkar DM. Evaluation for skin irritancy testing of developed formulations containing extract of Butea monosperma for its topical application. Int J Toxicol Appl Pharmacol. 2013;3:10-3.
OECD. 404, Guideline for the testing of Chemicals; 2021.
Sanna V, Peana AT, Mario D, Moretti L. Development of new topical formulations of diphenhydramine hydrochloride: in vitro diffusion and in vivo preliminary studies. Int J Pharm Technol Res. 2010;2:863-89.
Chen MX, Alexander KS, Baki G. Formulation and evaluation of antibacterial creams and gels containing metal ions for topical application, Hindawi publishing corporation. J Pharm 2016(5):1-10.
Maha HL, Sinaga KR, Sinaga KR, Masfria M, Masfria M. Formulation AND evaluation of miconazole nitrate nanoemulsion AND cream. Asian J Pharm Clin Res. 2018;11(3):319-21. doi: 10.22159/ajpcr.2018.v11i3.22056.
Premkumar A, Muthukumaran T, Ganesan V, Shanmugam R, Priyanka D. Formulation and evaluation of cream containing antifungal agents, antibacterial agents and corticosteroids, Hygeia. JD Med 2014;6(2):5-16.
Calvo MA, Arosemena EL, Shiva C, Adelantado C. Antimicrobial activity of natural plant extracts and essential oils. Science against microbial pathogens: communicating current research and technological advances; 2011. p. 1179-85.
Dethier B, Nott K, Fauconnier ML. (BIO) Synthesis, extraction and purification of garlic derivatives showing therapeutic properties. Commun Agric Appl Biol Sci 2013;78:149-55.
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