• JUNMONI NATH Department of Pharmaceutics, NEF College of Pharmacy, Saukuchi, lokhra, Guwahati 781040



Dendrimer, Synthesis, Application, Types, Toxicity


Dendrimers are monodisperse macromolecules with a lot of branches. Dendrimers' structural advantages enable them to play a key role in the field of nano-drug delivery. Dendrimers are ideal for a wide range of biological and industrial applications due to their unique behaviour. The bioactive substances may be readily encapsulated into the inside of the dendrimers or chemically conjugated or physically adsorbed onto the dendrimer surface, tailoring the carrier's desirable features to the active material's unique demands and therapeutic uses. This review summarizes on dendrimer production, characterization, advantages, and potential applications in drug delivery.


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Abd-El-Aziz AS, Agatemor C. Emerging opportunities in the biomedical applications of dendrimers. J Inorg Organomet Polym. 2018 Mar;28(2):369-82. doi: 10.1007/s10904-017-0768-5.

Noor A, Mahmood W, Afreen A, Uzma S. Dendrimers as novel formulation in nanotechnology-based targeted drug delivery. World J Pharm Pharm Sci. 2015;4:1509-23.

Tiwari AK, Gajbhiye V, Sharma R, Jain NK. Carrier mediated protein and peptide stabilization. Drug Deliv. 2010 Nov 1;17(8):605-16. doi: 10.3109/10717544.2010.509359, PMID 20879837.

Boas U, Christensen JB, Heegaard PM. Dendrimers in medicine and biotechnology: new molecular tools. Royal Society of Chemistry; 2006.

Svenson S, Tomalia DA. Dendrimers in biomedical applications-reflections on the field. Adv Drug Deliv Rev. 2005;57(15):2106-29. doi: 10.1016/j.addr.2005.09.018. PMID 16305813.

Patel RP. Dendrimers: A new innovation in drug delivery. Pharm Bio World. 2007;1:42-52.

Gillies ER, Frechet JM. Dendrimers and dendritic polymers in drug delivery. Drug Discov Today. 2005 Jan 1;10(1):35-43. doi: 10.1016/S1359-6446(04)03276-3, PMID 15676297.

Grayson SM, Frechet JM. Convergent dendrons and dendrimers: from synthesis to applications. Chem Rev. 2001 Dec 12;101(12):3819-68. doi: 10.1021/cr990116h, PMID 11740922.

Boas U, Christensen JB, Heegaard PM. Dendrimers in medicine and biotechnology: new molecular tools. Royal Society of Chemistry; 2006.

Caminade AM, Turrin CO, Laurent R, Ouali A, Delavaux Nicot B, editors. Dendrimers: towards catalytic, material and biomedical uses. John Wiley & Sons; 2011 Aug 31. p. 1-33.

Palmerston Mendes L, Pan J, Torchilin VP. Dendrimers as nanocarriers for nucleic acid and drug delivery in cancer therapy. Molecules. 2017 Sep;22(9):1401. doi: 10.3390/molecules22091401, PMID 28832535.

Shyma MS, Sheri PS. Dendrimers-a emerging tool for drug delivery. J Pharm Sci Res. 2020 Oct 1;12(10):1309-14.

Akbarzadeh A, Khalilov R, Mostafavi E, Annabi N, Abasi E, Kafshdooz T, Herizchi R, Kavetskyy T, Saghfi S, Nasibova A, Davaran S. Role of dendrimers in advanced drug delivery and biomedical applications: a review. Exp Oncol. 2018 Oct 1;40(3):178-83. doi: 10.31768/2312-8852.2018.40(3):178-83, PMID 30285011.

Tomalia DA, Naylor AM, Goddard Iii WA. Starburst dendrimers: molecular‐level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter. Angew Chem Int Ed Engl. 1990 Feb;29(2):138-75. doi: 10.1002/anie.199001381.

Esfand R, Tomalia DA. Poly(amidoamine)(PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discov Today. 2001 Apr 15;6(8):427-36. doi: 10.1016/s1359-6446(01)01757-3, PMID 11301287.

Schiavon O, Pasut G, Moro S, Orsolini P, Guiotto A, Veronese FM. PEG–ara-C conjugates for controlled release. Eur J Med Chem. 2004 Feb 1;39(2):123-33. doi: 10.1016/j.ejmech.2003.10.005, PMID 14987821.

Brana MF, Dominguez G, Saez B, Romerdahl C, Robinson S, Barlozzari T. Synthesis and antitumour activity of new dendritic polyamines–(imide–DNA-intercalator) conjugates potent Lck inhibitors. Eur J Med Chem. 2002 Jul 1;37(7):541-51. doi: 10.1016/s0223-5234(02)01362-4, PMID 12126773.

Hawker CJ, Wooley KL, Frechet JMJ. Unimolecular micelles and globular amphiphiles: dendritic macromolecules as novel recyclable solubilization agents. J Chem Soc Perkin Trans 1. 1993;12(12):1287-97. doi: 10.1039/P19930001287.

Pushkar S, Philip A, Pathak K, Pathak D. Dendrimers: nanotechnology derived novel polymers in drug delivery. Indian J Pharm Educ Res. 2006;40(3):153.

Yasukawa T, Ogura Y, Tabata Y, Kimura H, Wiedemann P, Honda Y. Drug delivery systems for vitreoretinal diseases. Prog Retin Eye Res. 2004 May 1;23(3):253-81. doi: 10.1016/j.preteyeres.2004.02.003, PMID 15177203.

Tripathy S, Das MK. Dendrimers and their applications as novel drug delivery carriers. J Appl Pharm Sci. 2013 Sep;3(09):142-9.

Svenson S, Tomalia DA. Dendrimers in biomedical applications-reflections on the field. Adv Drug Deliv Rev. 2005;57(15):2106-29. doi: 10.1016/j.addr.2005.09.018. PMID 16305813.

Esfand R, Tomalia DA. Poly(amidoamine)(PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications. Drug Discov Today. 2001 Apr 15;6(8):427-36. doi: 10.1016/s1359-6446(01)01757-3, PMID 11301287.

Tomalia DA. Birth of a new macromolecular architecture: dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry. Prog Polym Sci. 2005 Mar 1;30(3-4):294-324. doi: 10.1016/j.progpolymsci.2005.01.007.

Guo Z, Pedersen CM, Wang P, Ma M, Zhao Y, Qiao Y, Wang Y. d-glucose Isomerization with PAMAM dendrimers as environmentally friendly catalysts. J Agric Food Chem. 2021 Apr 21;69(17):5105-12. doi: 10.1021/acs.jafc.1c01088, PMID 33881848.

Jackson CL, Chanzy HD, Booy FP, Drake BJ, Tomalia DA, Bauer BJ, Amis EJ. Visualization of dendrimer molecules by transmission electron microscopy (TEM): staining methods and cryo-TEM of vitrified solutions. Macromolecules. 1998 Sep 8;31(18):6259-65. doi: 10.1021/ma9806155.

Caminade AM, Turrin CO. Dendrimers for drug delivery. J Mater Chem B. 2014;2(26):4055-66. doi: 10.1039/c4tb00171k, PMID 32261736.

Frechet JMJ, Hawker CJ, Gitsov I, Leon JW. Dendrimers and hyperbranched polymers: two families of three-dimensional macromolecules with similar but clearly distinct properties. J Macromol Sci A. 1996 Oct 1;33(10):1399-425. doi: 10.1080/10601329608014916.

D’Emanuele A, Attwood D. Dendrimer–drug interactions. Adv Drug Deliv Rev. 2005 Dec 14;57(15):2147-62. doi: 10.1016/j.addr.2005.09.012, PMID 16310283.

Welch P, Muthukumar M. Tuning the density profile of dendritic polyelectrolytes. Macromolecules. 1998 Aug 25;31(17):5892-7. doi: 10.1021/ma980198w.

Inoue K. Functional dendrimers, hyperbranched and star polymers. Prog Polym Sci. 2000 May 1;25(4):453-571. doi: 10.1016/S0079-6700(00)00011-3.

Lu Y, An L, Wang ZG. Intrinsic viscosity of polymers: general theory based on a partially permeable sphere model. Macromolecules. 2013 Jul 23;46(14):5731-40. doi: 10.1021/ ma400872s.

Dighe NS, Pattan SR, Musmade DS, Gaware VM, Hole MB, Butle SR, Nirmal DA. Chem inform abstract: convergent synthesis: a strategy to synthesize compounds of biological interest. Chem Inform. 2011 Jul 19;42(29). doi: 10.1002/chin.201129232.

Mohanraj VJ, Chen Y. Nanoparticles- a review. Trop J Pharm Res. 2006;5(1):561-73. doi: 10.4314/tjpr.v5i1.14634.

Maysinger D. Nanoparticles and cells: good companions and doomed partnerships. Org Biomol Chem. 2007;5(15):2335-42. doi: 10.1039/b704275b, PMID 17637950.

Duncan R, Izzo L. Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev. 2005 Dec 14;57(15):2215-37. doi: 10.1016/j.addr.2005.09.019, PMID 16297497.

Sideratou Z, Tsiourvas D, Paleos CM. Quaternized poly (propylene imine) dendrimers as novel pH-sensitive controlled-release systems. Langmuir. 2000 Feb 22;16(4):1766-9. doi: 10.1021/la990829v.

Mehta P, Kadam S, Pawar A, Bothiraja C. Dendrimers for pulmonary delivery: current perspectives and future challenges. New J Chem. 2019;43(22):8396-409. doi: 10.1039/C9NJ01591D.

Caminade AM, Laurent R, Delavaux Nicot B, Majoral JP. ’Janus’ dendrimers: syntheses and properties. New J Chem. 2012;36(2):217-26. doi: 10.1039/C1NJ20458K.

Cheng Y, Man N, Xu T, Fu R, Wang X, Wang X, Wen L. Transdermal delivery of nonsteroidal anti-inflammatory drugs mediated by polyamidoamine (PAMAM) dendrimers. J Pharm Sci. 2007 Mar 1;96(3):595-602. doi: 10.1002/jps.20745, PMID 17094130.

Klajnert B, Bryszewska M. Dendrimers: properties and applications. Acta Biochim Pol. 2001 Mar 31;48(1):199-208. doi: 10.18388/abp.2001_5127.

Kralj M, Pavelic K. Medicine on a small scale. EMBO Rep. 2003 Nov;4(11):1008-12. doi: 10.1038/sj.embor.7400017, PMID 14593436.

Trivedi V, Patel U, Bhimani B, Daslaniya D, Patel G, Vyas B. Dendrimer: polymer of 21st century. J Pharm Int J Pharm Res Bio-Sci. 2012;1:1-21.

Vandamme TF, Brobeck L. Poly(amidoamine) dendrimers as ophthalmic vehicles for ocular delivery of pilocarpine nitrate and tropicamide. J Control Release. 2005;102(1):23-38. doi: 10.1016/j.jconrel.2004.09.015, PMID 15653131.

Bai S, Thomas C, Ahsan F. Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular-weight heparin. J Pharm Sci. 2007 Aug 1;96(8):2090-106. doi: 10.1002/jps.20849, PMID 17286291.

Abbasi E, Aval SF, Akbarzadeh A, Milani M, Nasrabadi HT, Joo SW, Hanifehpour Y, Nejati Koshki K, Pashaei Asl R. Dendrimers: synthesis, applications, and properties. Nanoscale Res Lett. 2014 Dec;9(1):247. doi: 10.1186/1556-276X-9-247, PMID 24994950.

Kukowska Latallo JF, Candido KA, Cao Z, Nigavekar SS, Majoros IJ, Thomas TP, Balogh LP, Khan MK, Baker JR. Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer. Cancer Res. 2005 Jun 15;65(12):5317-24. doi: 10.1158/0008-5472.CAN-04-3921, PMID 15958579.

Kesharwani P, Jain K, Jain NK. Dendrimer as a nanocarrier for drug delivery. Prog Polym Sci. 2014 Feb 1;39(2):268-307. doi: 10.1016/j.progpolymsci.2013.07.005.

Parajapati SK, Maurya SD, Das MK, Tilak VK, Verma KK, Dhakar RC. Potential application of dendrimers in drug delivery: A concise review and update. J Drug Delivery Ther. 2016 Mar 14;6(2):71-88. doi: 10.22270/jddt.v6i2.1195.

Perez AP, Mundina Weilenmann C, Romero EL, Morilla MJ. Increased brain radioactivity by intranasal P-labeled siRNA dendriplexes within in situ-forming mucoadhesive gels. Int J Nanomedicine. 2012;7:1373-85. doi: 10.2147/IJN.S28261, PMID 22457595.

Padilla De Jesus OL, Ihre HR, Gagne L, Frechet JM, Szoka FC. Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation. Bioconjug Chem. 2002 May 15;13(3):453-61. doi: 10.1021/bc010103m, PMID 12009933.

Malik N, Evagorou EG, Duncan R. Dendrimer-platinate: a novel approach to cancer chemotherapy. Anticancer Drugs. 1999 Sep 1;10(8):767-76. doi: 10.1097/00001813-199909000-00010, PMID 10573209.

Lee CC, Gillies ER, Fox ME, Guillaudeu SJ, Frechet JM, Dy EE, Szoka FC. A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16649-54. doi: 10.1073/pnas.0607705103, PMID 17075050.

Bhadra D, Bhadra S, Jain S, Jain NK. A pegylated dendritic nanoparticulate carrier of fluorouracil. Int J Pharm. 2003 May 12;257(1-2):111-24. doi: 10.1016/s0378-5173(03)00132-7, PMID 12711167.

Lee SC, Parthasarathy R, Botwin K, Kunneman D, Rowold E, Lange G, Klover J, Abegg A, Zobel J, Beck T, Miller T, Hood W, Monahan J, McKearn JP, Jansson R, Voliva CF. Biochemical and immunological properties of cytokines conjugated to dendritic polymers. Biomed Microdevices. 2004 Sep;6(3):191-202. doi: 10.1023/B:BMMD.0000042048.18186.ff, PMID 15377828.



How to Cite

NATH, J. “DENDRIMERS: A REVIEW ON ITS SNYTHESIS, TYPES, PROPERTIES AND APPLICATIONS”. International Journal of Current Pharmaceutical Research, vol. 14, no. 2, Mar. 2022, pp. 21-25, doi:10.22159/ijcpr.2022v14i2.1964 .



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