PSYCHOPHARMACOLOGICAL SCREENING OF ETHANOLIC EXTRACT OF LANATA CAMARA LINN SEEDS
DOI:
https://doi.org/10.22159/ijcpr.2022v14i3.1962Keywords:
Lantana camara, Actophotometer, Elevated plus maze, Y maze, Rota rod, Soxhlet apparatus, Antianxiety activity, Anti psychotic activity, Muscle relaxant activityAbstract
Objective: To study the skeletal muscle relaxant, antipsychotic and anti anxiety activity of ethanolic extract of Lantana camaralinn seeds in male wistar albino mice.
Methods: The extract of the seeds of Lantana camaralinn was prepared by using Soxhlet extraction and the obtained extract is used for the evaluation of antianxiety activity, antipsychotic activity and muscle relaxant activity using male albino wistar mice.
Results: The results showed that the high dose (400 mg/kg) of the extract has shown significant anti anxiety, anti psychotic and skeletal muscle relaxant activities than the low dose (200 mg/kg).
Conclusion: we concluded that the plant Lantana camaralinn seeds has significant skeletal muscle relaxant, anti anxiety and anti psychotic activities as evidenced by the Rota rod, elevated plus maze, Y maze and acto photometer.
Downloads
References
Everitt BJ, Robbins TW. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci. 2005;8(11):1481-9. doi: 10.1038/nn1579, PMID 16251991.
Sudhakar P, Gopalakrishna HN, Ashok KS, Sekhar SS, Shishir M, Vinayak M, Vinod N. Antidepressant activity of aqueous extract of fruits of Emblica Officinalis in mice. Int J Appl Biol Pharmace Tech. 2010;1(2):449-54.
KD. Tripati essentials of medical pharmacology. 7th ed ch: 25. p. 356-9 ch: 32 p. 421-4, 466.
Varanasi KV. Neuropsychopharmacological studies on Indian Hypericum perforatum Linn. Phys D; 2000.
Newcomer JW. Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. CNS Drugs. 2005;19Suppl 1:1-93. doi: 10.2165/00023210-200519001-00001, PMID 15998156.
Silveira MCL, Sandner G, Graeff FG. Induction of fos immunoreactivity in the brain by exposure to the elevated plus-maze. Behavioural Brain Research. 1993;56(1):115-8. doi: 10.1016/0166-4328(93)90028-O.
Narahashi T. Neuroreceptors and ion channels as the basis for drug action: past, present, and future. J Pharmacol Exp Ther. 2000;294(1):1-26. PMID 10871290.
Published
How to Cite
Issue
Section
Copyright (c) 2022 SANA BUTOOL, RESHMA, MD FAHEEMUDDIN, ASIYA KHATOON, ISHRATH FATIMA
This work is licensed under a Creative Commons Attribution 4.0 International License.
