FORMULATION OF MAGNETIC NANOPARTICLES AND THEIR APPLICATIONS


Abbaraju Krishna Sailaja

Abstract


Over the past three decades, there has been a considerable research interest in the area of developing drug delivery using nanoparticles (NPs) as carriers for small and large molecules. Targeting delivery of drugs to the diseased lesions is one of the most important aspects of drug delivery system. They have been used in vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to the site of action. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. In order to see functionality and toxicity of nanoparticles invarious food and drug applications, it is important to establish procedures to prepare nanoparticles of a controlled size. NaturalControlled release of drugs from nanostructured functional materials, especially nanoparticles (NPs), is attracting increasing attention because of the opportunities in cancer therapy and the treatment of other ailments. The potential of magnetic NPs stems from the intrinsic properties of their magnetic cores combined with their drug loading capability and the biochemical properties that can be best owed on them by means of a suitable coating. This  review was mainly focused on different techniques for the preparation of magnetic nanoparticles and their application in various field. In addition to that some of the applications in the field of biomedicine were also explained.


| PDF |

References


Pedro Tartaj, Mar´ıa del Puerto Morales. The preparation of magnetic nanoparticles for applications in biomedicine. J. Phys. D: Appl. Phys. 2003;36 :R182–R197.

Parak WJ, Boudreau R, Gros ML, Gerion D, Zanchet D, Micheel CM,Williams SC, Alivisatos AP, Larabell CA. Cell motility and metastatic potential studies based on quantum dot imaging of phagokinetic tracks. Adv Mater .2002;14:882-885.

Sinani VA, Koktysh DS, Yun BG, Matts RL, Pappas TC, Motamedi M, Thomas SN, Kotov NA. Collagen coating promotes biocompatibility of semiconductor nanoparticles in stratified LBL films. Nano Letters. 2003; 3:1177-1182.

Zhang Y, Kohler N, Zhang M. Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake. Biomaterials. 2002; 23:1553-1561.

Gutwein LG, Webster TJ: Affects of alumina and titania nanoparticulates on bone cell function. American Ceramic Society 26 th Annual Meeting Conference Proceedings 2003 in press.

Roy I, Ohulchanskyy TY, Pudavar HE, Bergey EJ, Oseroff AR, Morgan J, Dougherty TJ, Prasad PN. Ceramic-based nanoparticles entrapping water-insoluble photo sensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy. J Am Chem Soc. 2003; 125:7860-7865.

Han M, Gao X, Su JZ, Nie S. Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nature Biotechnology. 2001; 19:631-635.

Reich DH, Tanase M, Hultgren A, Bauer LA, Chen CS, Meyer GJ. Biological applications of multifunctional magnetic nanowires. J Appl Phys. 2003; 93:7275-7280.

Cao YC, Jin R, Nam JM, Thaxton CS, Mirkin CA. Raman dye labeled nanoparticle probes for proteins. JACS. 2003; 125:14676-14677.

Pankhurst QA, Connolly J, Jones SK, Dobson J. Applications of magnetic nanoparticles in biomedicine. J Phys D: Appl Phys. 2003; 36:R167-R181.

Grief AD, Richardson G. Mathematical modelling of magnetically targeted drug delivery. J Magn Magn Mater. 2005; 293:455–463.

Neuberger T, Schopf B, Hofmann H, Hofmann M, von Rechenberg B. Superpara

magnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system. J Magn Magn Mater .2005; 293: 483–496.

McBain SC, Yiu HH, Dobson J Magnetic nanoparticles for gene and drug delivery. Int J Nanomedicine.2008; 3:169–180.

Reddy LH, Arias JL, Nicolas J, Couvreur P. Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. Chem Rev.2012. 112:5818–5878.

Primo FL, Michieleto L, Lacava ZGM, Bentley MVLB, Tedesco AC. Magnetic nanoemulsions as drug delivery system for Foscan_: skin permeation and retention in

vitro assays for topical application in photodynamic therapy (PDT) of skin cancer. J Magn Mater .2007;311:354–357.

Veiseh O, Gunn JW, Zhang M Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.Adv Drug Deliv Rev.2010. 62:284–304

Wahajuddin SA . Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers. Int J Nanomedicine.2012. 7:3445–3471.




About this article

Title

FORMULATION OF MAGNETIC NANOPARTICLES AND THEIR APPLICATIONS

Date

01-10-2013

Additional Links

Manuscript Submission

Journal

Innovare Journal of Life Sciences
Vol 1 Issue 3 2013 (Oct-Dec) Page: 6-9

Online ISSN

2321-550X

Statistics

231 Views | 702 Downloads

Authors & Affiliations

Abbaraju Krishna Sailaja
Associate Proffesor,RBVRR College of pharmacy,Barkatpura,Hyderabad


Refbacks

  • There are currently no refbacks.