EVALUATION AND PATHOBIOLOGICAL SIGNIFICANCE OF ZINC, SELENIUM, AND PLATELET LEVELS IN SICKLE CELL ANEMIA

  • NNODIM JOHNKENNEDY Department of Medical Laboratory Science, Faculty of Health Science, Imo State University, Owerri, Imo, Nigeria.
  • NJOKU CHUKWUDI JOSEPH Department of Pharmacology, Faculty of Basic Medical Sciences, Niger Delta University, Bayelsa, Nigeria.
  • OLY-ALAWUBA NKIRUKA Department of Nutrition and Dietetics, Faculty of Health Science, Imo State University, Owerri, Nigeria.
  • NWAOKORO JOAKIN CHIDOZIE Department of Public Health, Federal University of Technology, Owerri, Imo, Nigeria.
  • AMADI JOY Department of Nutrition and Dietetics, Faculty of Health Science, Imo State University, Owerri, Nigeria.
  • OKECHUKWU-EZIKE NGOZIKA C Department of Public Health, Federal University of Technology, Owerri, Imo, Nigeria. 5Department of Food Science, Faculty of Science, Imo State University, Owerri, Imo, Nigeria.

Abstract

Objectives: The serum zinc and platelet statuses of sickle cell patients attending General Hospital, Owerri, Nigeria, were investigated.


Methods: Fifty confirmed sickle cell patients (hemoglobin [Hb]SS) age 10–30 years were selected. Fifty normal subjects (HbAA) age 10–30 years were used as control. The zinc and platelets were determined using standard methods.


Results: The levels of serum zinc, selenium, and platelet were significantly decreased in sickle cell anemia (p<0.05) when compared with the control.


Conclusion: The result suggests that supplementation of sickle cell patients with food and drug-containing zinc might be helpful, particularly in wound healing, as zinc positively correlates with platelet counts. These low zinc, selenium, and platelets could represent a risk for sickle cell anemia.

Keywords: Zinc, Selenium, Platelet, Sickle cell anemia

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JOHNKENNEDY, N., JOSEPH, N. C., NKIRUKA, O.-A., CHIDOZIE, N. J., JOY, A., & NGOZIKA C, O.-E. (2020). EVALUATION AND PATHOBIOLOGICAL SIGNIFICANCE OF ZINC, SELENIUM, AND PLATELET LEVELS IN SICKLE CELL ANEMIA. Innovare Journal of Medical Sciences, 11-12. https://doi.org/10.22159/ijms.2020.v8i2.37003
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