EVALUATION AND PATHOBIOLOGICAL SIGNIFICANCE OF ZINC, SELENIUM, AND PLATELET LEVELS IN SICKLE CELL ANEMIA
Keywords:Zinc, Selenium, Platelet, Sickle cell anemia
Objectives: The serum zinc and platelet statuses of sickle cell patients attending General Hospital, Owerri, Nigeria, were investigated.
Methods: Fifty confirmed sickle cell patients (hemoglobin [Hb]SS) age 10–30 years were selected. Fifty normal subjects (HbAA) age 10–30 years were used as control. The zinc and platelets were determined using standard methods.
Results: The levels of serum zinc, selenium, and platelet were significantly decreased in sickle cell anemia (p<0.05) when compared with the control.
Conclusion: The result suggests that supplementation of sickle cell patients with food and drug-containing zinc might be helpful, particularly in wound healing, as zinc positively correlates with platelet counts. These low zinc, selenium, and platelets could represent a risk for sickle cell anemia.
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