Lung Cancer Therapy Using Naturally Occurring Products and Nano-technology

Authors

  • SYED SAIF IMAM IMAM Department of Pharmaceutical Sciences HIMT College of Pharmacy,

Keywords:

Theaflavins, Quercetin, Arctigenin, EGCG, Curcumin, Cinnamaldehyde, Lung Cancer, Nano-technology.

Abstract

Lung Cancer is a severe type of cancer with highest mortality rate among all cancers. Natural products such as Theaflavins, Quercetin, Arctigenin, EGCG, Curcumin and Cinnamaldehyde are quite capable anti-inflammatory and anti-cancerous agents which are able to suppress ERK-MAPK, JAK-STAT, p38, AMPK, PI3K/Akt,MAPK, mTOR, STAT3, and wnt/β-catenin signal transduction pathways. These APIs inhibits the inflammatory and proliferator enzymes such as COX-2, caspase-3, MMP-9, MMP-2, NF-κB, p53, Bcl-xL, Bcl-2, Mcl-1, miR-210, cyclin D1, iNOS, IL-1β, TNF-α, IFN-γ, IL-6, IL-1α. All the above properties clearly show the anti-cancerous potential, but the problems arise because of their instability at gastro-intestinal tract pH. All the compounds either degrade at gastric pH or losses their cancerous potential. New generation nano-particles such as transferosomes are quite stable at 7.4 pH and it efficacy and drug entrapment potential are better than other conventional nano-particle systems. If these APIs are added inside the nano-vesicular structure of transferosomes and then loaded in pMDI canisters such as fluorocarbon polymerization (FCP) plasma coated canisters with a better propellant such as HFA-134a and delivered with the help of spacers can cure lungs cancer economically, efficiently with minimal side effects and it also ensures that the cancer will not reoccur.

 

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Published

11-06-2022

How to Cite

IMAM, S. S. I. (2022). Lung Cancer Therapy Using Naturally Occurring Products and Nano-technology. Innovare Journal of Medical Sciences, 10(4). Retrieved from https://innovareacademics.in/journals/index.php/ijms/article/view/44993

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Section

Review Article(s)