AN EXPEDIENT APPROACH TO TREAT ASTHMA THROUGH NON-STEROIDAL, NATURAL TRANSFEROSOMES AEROSOL SYSTEM

Authors

  • SONAM SHARMA Department of Pharmaceutical Sciences, HIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India.
  • DIVYA KUMARI Department of Pharmaceutical Sciences, HIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India.
  • SHARUKH KHAN Department of Pharmaceutical Sciences, HIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India.
  • PRIYANKA PATHAK Department of Pharmaceutical Sciences, HIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India.
  • DEEKSHA KATIYAR Department of Pharmaceutical Sciences, HIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India.
  • SYED SAIF IMAM Department of Pharmaceutical Sciences, HIMT College of Pharmacy, Greater Noida, Uttar Pradesh, India.

DOI:

https://doi.org/10.22159/ijms.2022.v10i6.46451

Keywords:

Non-steroidal treatment of asthma, Curcumin, Formononetin, Matrine, Asthma, Nanoparticles, Transferosomes

Abstract

Asthma is the most common respiratory disease, affecting an estimated 262 million people and resulting in 461,000 fatalities in 2019. The treatment is available on the market, but it is quite expensive, and it also has serious adverse effects due to the high concentration of steroids in the medicine. If given effectively, curcumin, formononetin, and matrine’s anti-inflammatory properties can play a significant role in treatment. To improve the chemical stability and therapeutic potential of these active pharmaceutical ingredients (APIs) in the respiratory tract, a transferosomes system was designed, which encapsulates the APIs inside its vesicular structure and delivers them selectively to the inflamed cells. The DPPC layer will allow for efficient penetration, whereas Tween-80 will aid in deformability and lower interfacial tension, resulting in a small Z-average diameter, allowing for efficient penetration between layers of cells. The APIs’ stability at alkaline pH (7.6) is ensured by the nano-vesicular structure, which significantly increases cellular antioxidant activity and ferric reducing antioxidant power values. On the RAW264.7 cell line, the formulation will be tested for anti-inflammatory activity. Nuclear factor kappa B, tumor necrosis factor, interleukin (IL)-1, IL-2, IL-6, IL-8, IL-12, nitric oxide, and cyclooxygenase-2 are all reduced by curcumin, formononetin, and matrine. They also have an inhibitory effect on the MAPK signaling pathway, preventing extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38 from causing inflammation. This formulation can effectively treat asthma without the use of steroids, has no adverse effects, and is inexpensive.

References

Ribeiro A, Aguiar R, Morais-Almeida M. Biological therapies, asthma and coronavirus disease 2019. Curr Opin Allergy Clin Immunol 2021;21:597-601.

Gutierres VO, Campos ML, Arcaro CA, Assis RP, Baldan-Cimatti HM, Peccinini RG, et al. Curcumin pharmacokinetic and pharmacodynamic evidences in streptozotocin-diabetic rats support the antidiabetic activity to be via metabolite (s). Evid Based Complement Altern Med 2015;2015:678218.

Kay AB. Asthma and inflammation. J Allergy Clin Immunol 1991;87:893-910.

Galli SJ, Tsai M, Piliponsky AM. The development of allergic inflammation. Nature 2008;454:445-54.

Tulic MK, Christodoulopoulos P, Hamid Q. Small airway inflammation in asthma. Respir Res 2001;2:333-9.

To T, Stanojevic S, Moores G, Gershon AS, Bateman ED, Cruz AA, et al. Global asthma prevalence in adults: Findings from the cross-sectional world health survey. BMC Public Health 2012;12:1-8.

Trivedi M, Denton E. Asthma in children and adults-what are the differences and what can they tell us about asthma? Front Pediatr 2019;7:256.

Cipriani F, Calamelli E, Ricci G. Allergen avoidance in allergic asthma. Front Pediatr 2017;5:103.

Aggarwal BB, Yuan W, Li S, Gupta SC. Curcumin‐free turmeric exhibits anti‐inflammatory and anticancer activities: Identification of novel components of turmeric. Mol Nutr Food Res 2013;57:1529-42.

Wilken R, Veena MS, Wang MB, Srivatsan ES. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer 2011;10:12.

Tønnesen HH, Karlsen J. Studies on curcumin and curcuminoids. VI. Kinetics of curcumin degradation in aqueous solution. Z Lebensm Unters Forsch 1985;180:402-4.

Zhang F, Altorki NK, Mestre JR, Subbaramaiah K, Dannenberg AJ.Curcumin inhibits cyclooxygenase-2 transcription in bile acidand phorbol ester-treated human gastrointestinal epithelial cells. Carcinogenesis 1999;20:445-51.

Rao CV. Regulation of COX and LOX by curcumin. In: the Molecular Targets and Therapeutic uses of Curcumin in Health and Disease. Germany: Springer; 2007. p. 213-26.

Hidaka H, Ishiko T, Furuhashi T, Kamohara H, Suzuki S, Miyazaki M, et al. Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface: Impact on human pancreatic carcinoma cell growth by autocrine regulation. Cancer 2002;95:1206-14.

Liu L, Shang Y, Li M, Han X, Wang J, Wang J. Curcumin ameliorates asthmatic airway inflammation by activating nuclear factor‐E2‐ related factor 2/haem oxygenase (HO)‐1 signalling pathway. Clin Exp Pharmacol Physiol 2015;42:520-9.

Panaro MA, Corrado A, Benameur T, Paolo CF, Cici D, Porro C. The emerging role of curcumin in the modulation of TLR-4 signaling pathway: Focus on neuroprotective and anti-rheumatic properties. Int J Mol Sci 2020;21:2299.

Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC, et al. Inhibition of the NF-κB signaling pathway by the curcumin analog, 3, 5-Bis (2-pyridinylmethylidene)-4-piperidone (EF31): Anti-inflammatory and anti-cancer properties. Int Immunopharmacol 2012;12:368-77.

Jiang D, Rasul A, Batool R, Sarfraz I, Hussain G, Tahir MM, et al. Potential anticancer properties and mechanisms of action of formononetin. Biomed Res Int 2019;2019:5854315.

Wang W, Tanaka Y, Han Z, Higuchi CM. Proliferative response of mammary glandular tissue to formononetin. Nutr Cancer 1995;23:131-40.

Wang Y, Zhu Y, Gao L, Yin H, Xie Z, Wang D, et al. Formononetin attenuates IL-1β-induced apoptosis and NF-κB activation in INS- 1 cells. Molecules 2012;17:10052-64.

Liu Y, He J, Chen X, Li J, Shen M, Yu W, et al. The proapoptotic effect of formononetin in human osteosarcoma cells: Involvement of inactivation of ERK and Akt pathways. Cell Physiol Biochem 2014;34:637-45.

Kim MS, Park JS, Chung YC, Jang S, Hyun CG, Kim SY. Anti-inflammatory effects of formononetin 7-O-phosphate, a novel biorenovation product, on LPS-stimulated RAW 264.7 macrophage cells. Molecules 2019;24:3910.

Huang J, Chen X, Xie A. Formononetin ameliorates IL 13 induced inflammation and mucus formation in human nasal epithelial cells by activating the SIRT1/Nrf2 signaling pathway. Mol Med Rep 2021;24:832.

Li S, Liu X, Chen X, Bi L. Research progress on anti-inflammatory effects and mechanisms of alkaloids from Chinese medical herbs. Evid Based Complement Altern Med 2020;2020:1303524.

Zhang H, Chen L, Sun X, Yang Q, Wan L, Guo C. Matrine: A promising natural product with various pharmacological activities. Front Pharmacol 2020;11:588.

Lu S, Xiao X, Cheng M. Matrine inhibits IL-1β-induced expression of matrix metalloproteinases by suppressing the activation of MAPK and NF-κB in human chondrocytes in vitro. Int J Clin Exp Pathol 2015;8:4764.

Junior AL, Islam MT, Nicolau LA, De Souza LK, Araújo TD, De Oliveira GA, et al. Anti-inflammatory, antinociceptive, and antioxidant properties of anacardic acid in experimental models. ACS Omega 2020;5:19506-15.

Zhang Y, Wang S, Li Y, Xiao Z, Hu Z, Zhang J. Sophocarpine and matrine inhibit the production of TNF-α and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice. Int Immunopharmacol 2008;8:1767-72.

Modi CD, Bharadia PD. Transfersomes: New dominants for transdermal drug delivery. Am J Pharm Tech Res 2012;2:71-91.

Opatha SA, Titapiwatanakun V, Chutoprapat R. Transfersomes: A promising nanoencapsulation technique for transdermal drug delivery. Pharmaceutics 2020;12:855.

Bose S, Kim H. Evaluation of in vitro anti-inflammatory activities and protective effect of fermented preparations of Rhizoma Atractylodis Macrocephalae on intestinal barrier function against lipopolysaccharide insult. Evid Based Complement Altern Med 2013;2013:363076.

Published

25-10-2022

How to Cite

SHARMA, S., KUMARI, D., KHAN, S., PATHAK, P., KATIYAR, D., & IMAM, S. S. (2022). AN EXPEDIENT APPROACH TO TREAT ASTHMA THROUGH NON-STEROIDAL, NATURAL TRANSFEROSOMES AEROSOL SYSTEM. Innovare Journal of Medical Sciences, 10(6), 7–11. https://doi.org/10.22159/ijms.2022.v10i6.46451

Issue

Section

Review Article(s)

Most read articles by the same author(s)