EXCIPIENTS COPROCESSING INFLUENCE ON THE INTERACTING VARIABLES THAT AFFECT THE DISINTEGRATION PROPERTIES OF A PARACETAMOL TABLET FORMULATION

Authors

  • Abayomi Tolulope Ogunjimi
  • Gbenga Alebiowu Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Nigeria

Keywords:

coprocessing, binder, neem gum, disintegration time, crushing-strength-friabilitydisintegration-time ratio

Abstract

Objective: Neem gum (NMG) was coprocessed with lactose (LTC) at different ratios to produce novel binders.

Methods: The quantitative individual and interaction effects of formulation variables, nature of the coprocessed binders (N), concentration of coprocessed binders (C) and their tablet's relative density (D) on two disintegration properties–disintegration time (DT) and crushing strength-friability/disintegration time (CSFR/DT) ratio–of a Paracetamol tablet formulation was studied using a 23 factorial experimental design.

Results: The result showed that changing from neem gum to any of the coprocessed binders decreases the disintegration time of the Paracetamol tablet while an increase in C of the coprocessed binders led to an increase in the CSFR/DT ratio of the Paracetamol tablets. The extent of this decrease in disintegration time or increase in CSFR/DT depends on the proportion of NMG or LTC in the coprocessed binders.

Conclusion: The study concluded that the nature and proportions of individual materials coprocessed together would alter the influence C or D would have on disintegration time and CSFR/DT ratio. It further concludes that a 23 factorial analysis could be helpful to formulators in creating a design space for choosing optimal formulation and process variables that would produce desired product qualities.

Keywords: Coprocessing, binder, Neem gum, Disintegration time, Crushing-strength-friability/disintegration-time ratio

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References

Itiola OA, Pilpel N. Effects of interacting variables on the disintegration and dissolution of metronidazole tablets. Pharmazie 1996;51:987-9.

Upadrashta SM, Katikaneni PR, Nuessla NO. Chitosan as a tablet binder. Drug Dev Ind Pharm 1992;18:1701-8.

Alebiowu G, Adeagbo AA. Disintegrant properties of a paracetamol tablet formulation lubricated with co-processed lubricants. Farmacia 2009;57:500-10.

Symecko CW, Rhodes CT. Binder functionality in tabletted systems. Drug Dev Ind Pharm 1995;21:1091-114.

Adetogun GE, Alebiowu G. Properties of Delonix regia seed gum as a novel tablet binder. Acta Poloniae Pharm Drug Res 2009;66:433-8.

Debjit B, Chiranjib B, Jitendra Y, Chandira RM, Sampath KP. Emerging trends of disintegrants used in the formulation of solid dosage form. Der Pharm Lett 2010;2:495-504.

Nachaegari SK, Bansal AK. Coprocessed excipients for solid dosage forms. Pharm Technol 2004;28:52-64.

Ogunjimi AT, Alebiowu G. A quantitative study of the influence of coprocessing of binders on the mechanical properties of paracetamol tablets. Braz J Pharm Sci 2010;46:205-12.

Patel RP, Bhavsar M. Directly compressible materials via co-processing. Int J PharmTech Res 2009;1:745-53.

Ogunjimi AT, Alebiowu G. Flow and consolidation properties of Neem gum coprocessed with two pharmaceutical excipients. Powder Technol 2013;246:187-92.

Sharma P, Modi SR, Bansal AK. Co-processing of hydroxypropyl methylcellulose (HPMC) for improved aqueous dispersibility. Int J Pharm 2015;485:348-56.

Kulkarni GT, Gowthamarajan K, Dhobe RR, Yohanan F, Suresh B. Development of controlled release spheriods polysaccharide as a release modifier. Drug Delivery 2005;12:201-6.

De Azevedo EP. Chitosan hydrogels for drug delivery and tissue engineering applications. Int J Pharm Pharm Sci 2015;7:8-14.

Deshmukh AS, Aminabhavi TM. Pharmaceutical applications of various natural gums natural gums. Polysaccharides: Bioactivity and Biotechnology; 2015. p. 1933-67.

Lorke D. A new approach to practical acute toxicity testing. Arch Toxicol 1983;54:275-87.

Ogunjimi AT, Alebiowu G. Material and tableting properties of azadirachta indica gum with reference to official Acacia gum. Acta Pol Pharm 2014;71:107-18.

Woolfall RC. An approach to product formulation. Soap Perfume Cosmet London 1964;37:965-70.

Alebiowu G, Ojeleye OO. Influence of binder type on interacting variables acting on mechanical properties of sulfadimidine tablet formulation. Pharm Dev Technol New York 2007;12:153-8.

Mattsson S, Bredenberg S, Nyström C. Formulation of high tensile strength rapidly disintegrating tablets-evaluation of the effect of some binder properties. STP Pharm Sci 2001;11:211-20.

Washburn EW. The dynamics of capillary flow. Phys Rev 1992;17:273-81.

Alebiowu G, Itiola OA. The influence of pregelatinized starch disintegrants on interacting variables that act on disintegrant properties. Pharm Technol 2003;27:28-34.

Aggarwal P, Nautiyal U, Mali RR. A review on fast dissolving tablet. Int J Adv Sci Technol 2015;2:20-8.

Published

01-05-2016

How to Cite

Ogunjimi, A. T., and G. Alebiowu. “EXCIPIENTS COPROCESSING INFLUENCE ON THE INTERACTING VARIABLES THAT AFFECT THE DISINTEGRATION PROPERTIES OF A PARACETAMOL TABLET FORMULATION”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 5, May 2016, pp. 216-21, https://journals.innovareacademics.in/index.php/ijpps/article/view/10484.

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