COMPT (CATHECOL O METHYL TRANSFERASE) GENE AS GENETIC RISK FACTOR FOR JAVANESE SCHIZOPHRENIA
Objective: Several genes were suspected as a genetic marker of schizophrenia disease. This research was done to investigate the influence of Cathecol O-methyl transferase (COMPT) gene polymorphism toward incidence of schizophrenia on Javanese people.
Methods: There were two groups. The first group was Javanese schizophrenia patients, and the second group was not schizophrenia patients (control group). Each group contains 25 patients. The sample was taken from blood vein patients. Deoxyribonucleic acid (DNA) isolation was done using DNA isolation kit (QiagenÂ®). The method of genotyping was carried out by restriction fragment length polymorphism polymerase chain reaction (RFLP PCR) followed by digestion by Hin1 II enzyme.
Results: The results of this study showed that 64 % HH allele and 36 % LH allele of COMPT gene (G21881A) were found on Javanese schizophrenia while 76 % HH and 24 % LH allele were found on the control group. Odd ratio (OR) LH allele was 1,781 and OR HH allele was 0,561
Conclusion: The presence of LH allele of COMPT gene A1625G increases the risk of schizophrenia on Javanese people. The COMPT gene (G21881A) is a genetic risk factor for Schizophrenia disease on Javanese people.
Keywords: Schizophrenia, Javanese, COMPT gene
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