ANXIOLYTIC ACTIVITY OF MARINE MACROALGAE SARGASSUM ILICIFOLIUM AND PADINA TETRASTOMATICA IN MICE

Authors

  • Subhash R. Yende Department of Pharmacology, Gurunanak College of Pharmacy, Nagpur (INDIA)
  • Uday N. Harle
  • Abhay M. Ittadwar

Keywords:

Sargassum ilicifolium, Padina tetrastomatica, Brown algae, Anxiolytic activity

Abstract

Objective: The present study was designed to investigate an anxiolytic effect of chloroform and ethanol extract of Sargassum ilicifolium (SI) and Padina tetrastomatica (PT) in mice.

Methods: Acute toxicity study was done as per OECD 423 guidelines. Based on acute toxicity studies, doses of 200, 400 and 600 mg/kg of SI and PT extracts were selected, and the anxiolytic activity was assessed using Elevated plus maze (EPM) and light/dark exploration (L/DE) tests.

Results: Diazepam (2 mg/kg), the ethanol extract of SI (400 mg/kg) as well as ethanol extract of PT (600 mg/kg) significantly increased time spent and entries into the open arm in EPM test. In L/DE test Diazepam, chloroform extract (600 mg/kg) and ethanol extract (400 mg/kg) of SI as well as chloroform extract (600 mg/kg) and ethanol extract (600 mg/kg) of PT significantly increased time spent in light box and transition between the boxes.

Conclusion: in the present investigation, ethanol extract at 400 and chloroform extract at 600 mg/kg of Sargassum ilicifolium as well as ethanol extract at 400 and 600 mg/kg and chloroform extract at 600 mg/kg of Padina tetrastomatica exhibited an anxiolytic effect in the experimental model of anxiety. However, additional research will be necessary to investigate the mechanism underlying this anxiolytic activity.

Keywords: Sargassum ilicifolium, Padina tetrastomatica, Brown algae, Anxiolytic activity

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Published

01-05-2016

How to Cite

Yende, S. R., U. N. Harle, and A. M. Ittadwar. “ANXIOLYTIC ACTIVITY OF MARINE MACROALGAE SARGASSUM ILICIFOLIUM AND PADINA TETRASTOMATICA IN MICE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 5, May 2016, pp. 97-101, https://journals.innovareacademics.in/index.php/ijpps/article/view/10582.

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