FORMULATION AND EVALUATION OF ORAL SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM OF CANDESARTAN CILEXETIL
Abstract
Objective: The objective of our investigation was to formulate a liquid self micro emulsifying drug delivery system (SMEDDS) of candesartan cilexetil that could improve its solubility, stability, and oral bioavailability.
Methods: The prepared SMEDDS was the concentrate of drug, oil, surfactant, cosurfactant. The formulation was evaluated for various tests like solubility, Drug-surfactant compatibility, particle size, zeta potential, in vitro dissolution, etc.
Results: The optimized formulation C7IIB showed drug release (99.91%), droplet size (9.15 nm), Zeta potential (-23.2), viscosity (0. 8824 cP) and infinite dilution capability. In vitro drug release of the C7IIB was highly significant (p<0.05) as compared to marketed conventional tablet (M).
Conclusion: The present investigation shows that candesartan cilexetil Self microemulsifying drug delivery system can be formulated as unit dosage form. The C7IIB can be further used for the preparation of various Solid SMEDDS(S-SMEDDS) formulations.
Keywords: Self microemulsifying drug delivery system, Candesartan cilexetil, Drug release, Stability study, Bioavailability
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References
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