A RARE INSTANCE OF DIASTASE/PEPSIN – INDUCED HYPERSENSITIVITY REACTION


Navin Patil, Karthik Rao N, Handattu Manjunatha Hande, A Avinash, Raghavendra Rao, Sushil Kiran Kunder, Anurag Pathak, Talha Ahmed

Abstract


Diastase/Pepsin combination supplements are very commonly prescribed in clinical practice, mainly in the adult population. The chief indication for such use is indigestion or dyspepsia, wherein concomitant medication with proton pump inhibitors and antiemetics is also advised. Hypersensitivity reactions, though theoretically plausible with the use of digestive enzymes, there are no cases reported in the medical literature, to the best of our knowledge. This is one such case of hypersensitivity secondary to the administration of digestive enzymes in an adult Indian male.

Keywords: Digestive enzymes, Rash, Maculopapular, Allergy


Keywords


Digestive enzymes; Rash; Maculopapular; Allergy

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References


Harmon RC, Peura DA. Evaluation and management of dyspepsia. Ther Adv Gastroenterol 2010;3:87-98.

Barrett KE, Barman SM, Boitano S, Brooks HL. Gastrointestinal physiology. In: Ganong’s review of medical physiology. 23rd edition. The McGraw-Hill Companies; 2010.

https://www.mims.com/India/drug/info/ARISTOZYME/. [Last accessed on 03 Dec 2015].

http://www.drugsupdate.com/brand/generic/Diastase+Pepsin/48836/2. [Last accessed on 03 Dec 2015].

Stone SF, Phillips EJ, Wiese MD, Heddle RJ, Brown SGA. Immediate-type hypersensitivity drug reactions. Br J Clin Pharmacol 2014;78:1-13.




About this article

Title

A RARE INSTANCE OF DIASTASE/PEPSIN – INDUCED HYPERSENSITIVITY REACTION

Keywords

Digestive enzymes; Rash; Maculopapular; Allergy

Date

30-03-2016

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 8, Issue 5, 2016 Page: 421-422

Online ISSN

0975-1491

Statistics

64 Views | 79 Downloads

Authors & Affiliations

Navin Patil
Dept of Pharmacology, Kasturba Medical College, Manipal University, Manipal
India

Karthik Rao N

Handattu Manjunatha Hande

A Avinash

Raghavendra Rao

Sushil Kiran Kunder

Anurag Pathak

Talha Ahmed


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