EVALUATION OF ANTICONVULSANT ACTIVITY OF MIMOSA PUDICA ROOT LINN IN SWISS ALBINO MICE
Objective: To evaluate the anticonvulsant activity of ethanolic extract of Mimosa pudica root (EMPR) in experimental mice models.
Methods: Ethanolic extract of root parts of Mimosa pudica (EMPR) was prepared by a continuous method using soxhlet apparatus. EMPR in doses of 1000, 2000 mg/kg body wt along with valproate were administrated to albino mice by oral route and anti-epileptic activity was assessed by maximal electroshock (MES) and pentylenetetrazole (PTZ) induced seizure models. Abolition of tonic hind limb extension phase and an increase in seizure latency period, when compared to control group, were taken as a measure of protection in MES and PTZ induced convulsion models respectively.
Results: EMPR in the dose of 1000 and 2000 mg/kg body wt of mice showed significant anti-epileptic property in both MES and PTZ induced seizure models. There was a significant abolition of tonic hind limb extension phase in MES model. There was also a significant increase in seizure latency period in PTZ induced seizure model.
Conclusion: Results suggest that ethanolic extract of Mimosa pudica roots possess significant anti-epileptic activity. Further investigations are required to determine its active constituents and also its antiepileptic mechanism of action.
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