EVALUATION OF ANTICONVULSANT ACTIVITY OF MIMOSA PUDICA ROOT LINN IN SWISS ALBINO MICE

  • Prathima C. Dept. of Pharmacology, JSS Medical college (A Constituent College of JSS University), Mysore
  • Shashikumara . PG MSc Student of Medical Pharmacology, Dept. of Pharmacology, JSS Medical college (A Constituent College of JSS University), Mysore
  • Thippeswamy T. Dept. of Medicine, JSS Medical college (A Constituent College of JSS University), Mysore
  • Jayanthi M. K. Dept. of Pharmacology, JSS Medical college (A Constituent College of JSS University), Mysore

Abstract

Objective: To evaluate the anticonvulsant activity of ethanolic extract of Mimosa pudica root (EMPR) in experimental mice models.

Methods: Ethanolic extract of root parts of Mimosa pudica (EMPR) was prepared by a continuous method using soxhlet apparatus. EMPR in doses of 1000, 2000 mg/kg body wt along with valproate were administrated to albino mice by oral route and anti-epileptic activity was assessed by maximal electroshock (MES) and pentylenetetrazole (PTZ) induced seizure models. Abolition of tonic hind limb extension phase and an increase in seizure latency period, when compared to control group, were taken as a measure of protection in MES and PTZ induced convulsion models respectively.

Results: EMPR in the dose of 1000 and 2000 mg/kg body wt of mice showed significant anti-epileptic property in both MES and PTZ induced seizure models. There was a significant abolition of tonic hind limb extension phase in MES model. There was also a significant increase in seizure latency period in PTZ induced seizure model.

Conclusion: Results suggest that ethanolic extract of Mimosa pudica roots possess significant anti-epileptic activity. Further investigations are required to determine its active constituents and also its antiepileptic mechanism of action.

Keywords: Epilepsy, Mimosa pudica root extract, MES, PTZ model

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References

1. Sander JW, Shorvon SD. Epidemiology of the epilepsy. J Neurol Neurosurg Psychiatry 1996;6:433-43.
2. Ngugi AK, Bottemley C, Kleinschmidt I. Estimation of the burden of active and life-time epilepsy: a meta-analytic approach. Epilepsia 2010;51:883-90.
3. Porter RJ, Meldrum BS. Antiseizures drugs. In: Katzung BG, Masters SB, Trevor AJ. Basic and Clinical Pharmacology. 11th ed. New Delhi: Tata-McGraw Hill; 2009. p. 399-400.
4. Lowenstein DH. Seizures and epilepsy. In: Fauci, Braunwald, Kasper, Hauser, Longo, Jameson. Harrisons Principles of Internal Medicine. 17th ed. USA: McGraw Hill; 2008. p. 2498-9.
5. McNamara JO. Pharmacotherapy of epilepsies. In: Brunton LL, Lazo JS, Parker KL. Goodman and Gillman’s the Pharmacological Basis of Therapeutics. 11th ed. USA: McGraw Hill; 2006. p. 501-4.
6. Chauhan, Bhagirath S, Johnson, Davi E. Germination, emergence and dormancy of Mimosa pudica. Weed Biol Manag 2009;9:38-45.
7. Tamilarasi T, Ananthi T. Photochemical analysis and microbial activity of Mimosa pudica activity. Res J Chem Sci 2012;2:72-4.
8. Baby Joseph, Jency George, Jeevitha Mohan. Pharmacology and traditional uses of Mimosa pudica. Int J Pharm Sci Drug Res 2013;5:41-4.
9. Srivasthava Varnika, Sharma Ashish, Alam Imran. A review on ethnomedical and traditional uses of Mimosa pudica. Int Res J Pharm 2012;3:41-4.
10. Naveen Alasyam, Mannala Sunil, T Jayasree, K Vinay Kumar, Ch Nagesh, Narapogu Venkatanarayana. Evaluation of the anticonvulsant activity of alcoholic extract of Mimosa pudica in swiss albino rats. J Chem Pharm Res 2014;6:1175-9.
11. Maignana kumar R, Ruckmani A, Saradha S, Arunkumar R, Lakshmipathy prabhu R, Madhavi E, et al. Evaluation of the antiepileptic activity of Vetiveria zizanioides oil in Mice. Int J Pharm Sci Rev Res 2014;25:248-51.
12. Harbone JB. Phytochemical methods. a guide to modern techniques of plant analysis. 2nd Ed. Chapman and Hall, London; 1984. p. 274-84.
13. OECD Guidance Document on Acute Oral Toxicity. Environmental Health and Safety Monograph Series on Testing and Assessment; 2001.
14. Vogel HG. Anticonvulsant activity. In: Vogel WH, Scholkens BA, Sandow J, Muller G, Vogel WF. Drug discovery and evaluation pharmacological assays. 2nd ed. New York: Springer Press; 2002. p. 423-87.
15. Jerome E, Timothy AP. A Comprehensive Textbook. 2nd ed. Philadelphia: Lippincott Williams and Wilkins: What is Epilepsy; 1997. p. 1–7.
16. Satoskar RS, Bhandarkar SD. 12th ed. Mumbai: Popular Prakashan. Pharmacology and Pharmacotherapeutics; 1991. p. 10.
17. Rogawski MA, Porter RJ. Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising development stage compounds. Pharmacol Rev 1990;42:223-86.
18. De Sarro A, Cecchetti V, Fravoloni V, Naccari F, Tabarrinia O, De Sarro G. Effects of novel 6-desfluoroquirolones and classic quinolones on pentylenetetrazole-induced seizure in mice. Antimicrob Agents Chemother 1999;43:1729-36.
19. Tripathi KD. Essentials of medical pharmacology. 7th ed. New Delhi. Jaypee Publishers; 2013. p. 417.
20. Ngo Bum E, Dawack DL, Schmutz M, Rakotonirina A, Rakotonirina SV, Portet C, et al. Anticonvulsant activity of Mimosa pudica decoction. Fitoterapia 2004;75:309.
21. Kasture VS, Kasture SB, Chopde CT. Anticonvulsive activity of Butea monosperma flowers in laboratory animals. Pharmacol Biochem Behav 2002;72:965-72.
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C., P., S. ., T. T., and J. M. K. “EVALUATION OF ANTICONVULSANT ACTIVITY OF MIMOSA PUDICA ROOT LINN IN SWISS ALBINO MICE”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 9, Sept. 2016, pp. 49-52, doi:10.22159/ijpps.2016.v8i9.11716.
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