ESSENTIAL OILS AND METHYLGLYOXAL: A POSSIBLE ALTERNATIVE TREATMENT FOR ANTIBIOTIC RESISTANT BACTERIAL INFECTIONS

  • Erin Cieslak Department of Biology, Monmouth University, West Long Branch, NJ, USA
  • James P. Mack Department of Biology, Monmouth University, West Long Branch, NJ, USA
  • Albert Rojtman Department of Pathology, Meridian Health, Jersey Shore University Medical Center, Neptune, NJ, USA

Abstract

Objective: Essential oils are of significant interest in today’s world of healthcare because these compounds have a variety of medicinal properties. In this study, we evaluated the in vitro antibiotic role of essential oils as a possible alternative treatment in combatting Methicillin-resistant Staphylococcus aureus (MRSA).

Methods: In conjunction with carrier oils, three essential oils (cassia, cinnamon bark, and thyme), as well as methylglyoxal were tested on MRSA using the Kirby-Bauer disc diffusion method.

Results: The minimum inhibitory concentration of each tested essential oil and methylglyoxal in carrier oil was determined to be 25% essential oil and 75% carrier oil mixture. This concentration worked much more effectively than the standard antibiotic, vancomycin, which is currently used to treat MRSA infections.

Conclusion: Antibacterial emollients made from naturally occurring products like essential oils can be cost-effective alternatives to antibiotics. The results of this research show that these emollients are more effective against MRSA than standard antibiotics in cell culture.

Keywords: Methicillin-resistant Staphylococcus aureus, Essential oils, Cassia, Cinnamon bark, Thyme, Methylglyoxal, Antibiotic resistance

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References

1. Spellberg B, Bartlett J, Gilbert D. The future of antibiotics and resistance. N Engl J Med 2013;368:299-302.
2. Davies J, Davies D. Origins and evolution of antibiotic resistance. Microbiol Mol Biol Rev 2010;74:417-33.
3. Cui L, Iwamoto A, Lian JQ, Neoh HM, Maruyama T, Horikawa Y, et al. Novel mechanism of antibiotic resistance originating in vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother 2006;50:428-38.
4. Amoako D, Bester L, Somboro A, Baijnath S, Govind CN, Essack SY. Plasmid-mediated resistance and virulence mechanisms in the private health sector in Kwa Zulu-Natal, South Africa: an investigation of methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates collected during a three-month period. Int J Infect Dis 2016;46:38-41.
5. The White House. National Strategy for Combating Antibiotic-Resistant Bacteria. Washington DC. The Center for Disease Control; 2014.
6. Lawless, Julia. The illustrated encyclopedia of essential oils: The complete guide to the use of oils in aromatherapy and herbalism. New York: Element Books Limited; 1995.
7. Sharma P, Mack J, Rojtman A. Ten highly effective essential oils inhibit the growth of Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin Sensitive Staphylococcus aureus (MSSA). Int J Pharm Pharm Sci 2013;5:52-4.
8. Qureshi W, Palayekar V, Dayan E, Mack J, Rojtman A. Combating the antibiotic resistance threat. Int J Pharm Pharm Sci 2015;7:68-72.
9. Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol 1966;45:493-6.
10. Liu C, Bayer A, Cosgrove SE, Daum RS, Fridkin SK, Gorwitz RJ, et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis 2011;52:1-38.
11. Rutala W, Weber D. Guideline for disinfection and sterilization in healthcare facilities. Chapel Hill (NC): The Center for Disease Control; 2008.
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How to Cite
Cieslak, E., J. P. Mack, and A. Rojtman. “ESSENTIAL OILS AND METHYLGLYOXAL: A POSSIBLE ALTERNATIVE TREATMENT FOR ANTIBIOTIC RESISTANT BACTERIAL INFECTIONS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 9, Sept. 2016, pp. 107-10, doi:10.22159/ijpps.2016.v8i9.12242.
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Original Article(s)