• Jithendra Kumara K.s. Department of Chemistry, Sahyadri Science College, Shivamogga, Karnataka, INDIA
  • Krishnamurthy G. Department of Chemistry, Sahyadri Science College, Shivamogga, Karnataka, INDIA
  • Sunil Kumar N. Department of Chemistry, Sahyadri Science College, Shivamogga, Karnataka, INDIA


Objective: The main objectives of this research work is the synthesis and characterization of biologically potential triazole ring containing the Schiff base legend and their transition metal complexes, followed by screenings of their antimicrobial and anthelmintic activity the results of antimicrobial activity were compared with docking scores.

Methods: The coordination complexes of Co(II), Cu(II), Fe(III) and Zn(II) with Schiff base derived ligand 4-(1H-1,2,4-triazol-1-ylmethyl) aniline and substituted aldehydes have been synthesized. The complexes are characterized by elemental analysis, conductivity measurements, electronic, IR, and 1H NMR spectral data. The synthesized compounds were also screened In vitro antimicrobial activity was carried out according to diffusion method by using agar and potato dextrose agar at 100, 500 and 700 mg/ml concentrations in DMF. HEX 8.0 programmers were used to perform the docking experiments on nucleotide of S. typhi at as ligand [PDB: 3B6O].

Results: Schiff base ligand and their transition metal complexes were studied for antimicrobial activity as well as docking. The results of both studies concluded that 4a, 4c and 4d compounds are more active in minimum inhibition concentration (30μg/ml) against Staphylococcus aureus (S. aureus), Salmonella typhi (S. typlei) bacteria and Penicillium chrysogenum (P. Crysogenum) fungi. The compounds showed highest docking score (-257.47,-275.61 and-280.17 respectively) with the secondary structure of the alpha-amylase with a nucleotide from s. typhi in the solid model. In the study of anthelmintic activity among these three compounds, 4d compound exhibits more activity compared with the standard.

Conclusion: The compounds 4a, 4c and 4d were found to be more promising pharmacological activity this observation may promote a further development of this triazole group of compounds which may lead to better pharmacological profile than standard drugs. 


Keywords: Schiff bases, Triazoles, Metal complexes, Antimicrobial activity, Docking study


Download data is not yet available.


1. Poojari S, Naik PP, Krishnamurthy G. Synthesis of macrocycles containing 1,3,4-oxadiazole and pyridine moieties. Tetrahedron Lett 2014;55:305–9.
2. Afanas’ev IB, Dorozhko AI, Brodskii AV, Kostyuk VA, Potapovitch AI. Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochem Pharmacol 1989;38:1763-39.
3. Namratha B, Santosh LG. 1,2,4-Triazoles: synthetic strategies and pharmacological profiles. Int J Pharm Pharm Sci 2014;6:73-80.
4. Mansoory JH, Rajput SS. Synthesis, reactivity and biological evaluation of Triazole: recent developments. Int J Pharm Pharm Sci 2015;7:20-32.
5. Poojari S, Naik PP, Krishnamurthy G. One-pot synthesis of thieno [2,3-d] pyrimidin-4-ol derivatives mediated by polyphosphonic anhydride. Tetrahedron Lett 2012;53:4639–43.
6. Supuran CT, Barboiu M, Luca C, Pop E, Brewster ME, Dinculescu A. Carbonic anhydrase activators. Part 14. Syntheses of mono and bis-pyridinium salt derivatives of 2-amino-5-(2-aminoethyl)-and 2-amino-5-(3-aminopropyl)-1,3,4-thiadiazole and their interaction with isozyme II. Eur J Med Chem 1996;31:597-606.
7. Patil BS, Krishnamurthy G, Naik HB, Latthe PR, Ghate M. Synthesis, characterization and antimicrobial studies of 2-(4-methoxy-phenyl)-5-methyl-4-(2-arylsulfanyl-ethyl)-2,4-dihydro-[1,2,4] triazolo-3-ones and their corresponding sulfones. Eur J Med Chem 2010;45:3329–34.
8. Shashikumara ND, Krishnamurtya G, Bhojya Naik HS. An expeditious synthesis of 5-bromo-3-(1-methyl-1,2,3,6-tetra-hydropyridin-4-yl)-1H-indole. J Pharm Res 2011;4:2168-9.
9. Patil SB, Krishnamurthy G. Synthesis of some novel 1,2,4-triazole and 1,3,4-oxadiazole derivatives of biological interest. Med Chem Res 2013;22:3341-9.
10. Arjan W, Kleij, Robertus JM, Gebbink K, Paul AJ, van den Nieuwenhuijzen, et al. Halide-assisted macrocyclic ring formation in cyclometalated carbosilane dendrimers with 1 [C6H3(CH2NMe2)-4-(PdCl)-3] peripheral groups: application as aldol condensation catalysts. Organometallics 2001;20:634-47.
11. Vicente J, Llamas IS, Cuadrado J. Ortho-metalated primary amines. 6.1 the first synthesis of six-membered palladacycles from primary amines containing electron-withdrawing substituents: end of the limiting rules of cope and friedrich on cyclopalladation of benzyl and phenethylamines. Organo-metallics 2003;22:5513-7.
12. Lavastre O, Touzani R, Garbacia S. Thin layer chromatography for the detection of unexpected reactions in organometallic combinatorial catalysis. Adv Synth Catal 2003;345:974-7.
13. Nishinaga A, Yamada T, Fujisawa H, Ishizakik. Catalysis by cobalt Schiff complexes in the oxygenation of alkenes on the mechanism of ketonization. T Mol Catal 1988;48:249-64.
14. Chakraborty H, Paul N, Rahman ML. Catalytic activities of Schiff base aqua complexes of copper(II) towards hydrolysis of amino acid esters. Trans Met Chem (Lond) 1994;19:524-6.
15. Krishnamohan Sharma CV. Crystal engineering-where do we go from here. Crystal Growth Design 2002;2:465–74.
16. Bentiss F, Traisnel M, Gengembre L, Largrene MA. A new triazole derivative as an inhibitor of the acid corrosion of mild steel: electrochemical studies, weight loss determination, SEM and XPS. Appl Surf Sci 1999;152:237-49.
17. Desai PS, Indorwala NS. Triazoles used as a corrosion inhibitor for mild steel in hydrochloric acid. Int J Curr Microbiol Appl Sci 2015;4:928-38.
18. Shashikumara ND, Krishnamurtya G, Bhojya Naik HS, Lokesh MR, Jithendra Kumara KS. Synthesis of new biphenyl-substituted quinoline derivatives, preliminary screening and docking studies. J Chem Sci 2014;126:205–12.
19. Ramesh S Yamgar, Y Nivid, Satish Nalawade, Mustapha Mandewale, RG Atram, et al. Novel zinc(II) complexes of heterocyclic ligands as antimicrobial agents: synthesis, characterization, and antimicrobial studies 2014.
20. Roger JS, Asitha A, Scot C, John L, Mohammed A, Kashem HK, et al. Hit-to-lead studies on benzimidazole inhibitors of ITK: discovery of a novel class of kinase inhibitors. Bioorg Med Chem Lett 2007;17:3660-5.
21. Ozden OG, Taner E, Hakan G, Sulhiye Y. Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers. Bioorg Med Chem Lett 2007;17:2233-6.
273 Views | 634 Downloads
How to Cite
K.s., J. K., K. G., and S. K. N. “SYNTHESIS, CHARACTERIZATION, IN VITRO ANTIMICROBIAL, ANTHELMINTIC AND DOCKING STUDIES OF NEW 2-[(E)-{[4-(1H-1,2,4-TRIAZOL-1 YLMETHYL)PHENYL]IMINO} METHYL]PHENOL, AND THEIR COMPLEXES WITH 3D METAL IONS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, no. 9, Sept. 2016, pp. 134-9, doi:10.22159/ijpps.2016.v8i9.12611.
Original Article(s)