METHYL SALICYLATE MICROEMULSION BASED SYSTEMS. PART I: EFFECT OF ADDITIVES ON THE PHYSICOCHEMICAL PROPERTIES

  • Warunee Leesajakul Department of Pharmaceutical Technology Faculty of Pharmaceutical Science Huachiew Chalermprakiet University 18/18 Bangna-Trad Road Bangplee, Samutprakarn 10540, Thailand
  • Charanai Taworn Department of Pharmaceutical Technology Faculty of Pharmaceutical Science Huachiew Chalermprakiet University 18/18 Bangna-Trad Road Bangplee, Samutprakarn 10540, Thailand
  • Sunee Charnnarong Department of Pharmaceutical Technology Faculty of Pharmaceutical Science Huachiew Chalermprakiet University 18/18 Bangna-Trad Road Bangplee, Samutprakarn 10540, Thailand

Abstract

Ojectives: The objective was to determine the use of methyl salicylate, the oily active substance, as oil phase in a given surfactant system of Tween 20-IPA(1:1) in microemulsion preparation and also to investigate the effects of additives in the oil phase as well as their amounts on the physicochemical properties of such microemulsions.

Methods: The pseudoternary phase diagram of methyl salicylate/Tween 20-IPA(1:1)/water system was first constructed as control. Then, other additive-containing systems were investigated to illustrate their phase behaviors. Each additive was incorporated at three different weight ratios of methyl salicylate to additive varying as 3:1, 2:1, 1:1. Afterwards the single phase liquid systems composed of 15% oil phase in the absence and the presence of additives, 50% the Tween 20-IPA (1:1) mixture, and 35% water were prepared and characterized.

Results: Methyl salicylate was successfully used as oil phase in microemulsion preparation. All obtained formulations in the absence and the presence of additives were o/w microemulsions. They showed acceptable physicochemical properties of microemulsion characteristics, which had low viscosity with Newtonian flow. After long term stability for 1 year, the methyl salicylate microemulsion showed good physical stability. The systems containing menthol, isopropyl palmitate or isopropyl myristate as additive at the methyl salicylate-additive weight ratios of 3:1 and 2:1 also showed good physical appearance.

Conclusions: Menthol, IPP and IPM were proper additives in this study at the methyl salicylate-additive weight ratios of 3:1 and 2:1.

Keywords: Methyl salicylate/Tween 20-IPA, Methyl salicylate, Microemulsions.

 

Keywords: Methyl salicylate/Tween 20-IPA, Methyl salicylate, Microemulsions.

Downloads

Download data is not yet available.

References

1. Sweetman SC., editor. The complete drug reference2011.
2. Awang DVC. Tyler’s Herbs of Choice:The Therapeutic Use of Phytomedicinals2009.
3. Attwood D, Kreuter J. Microemulsions. In Kreuter J:editor. Colloidal Drug Dlivery Systems. New York: Maecel Dekker; 2004. p. 31-65.
4. Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Adv Drug Deliver Rev- 2012;64:175-93.
5. Delgado-Charro MB, Iglesias-Vilas G, Blanco-Méndez J, López- Quintela MA, Marty J, Guy RH. Delivery of a hydrophilic solute through the skin from novel microemulsion systems. Biopharm 1997;43:37-42.
6. Wu H, Ramachandran C, Weiner ND, Roessler BJ. Topical transport of hydrophilic compounds using water-in-oil nanoemulsions. Int J Pharm 2001;220(1-2):63-75.
7. Kreilgaard M. Influence of microemulsions on cutaneous drug delivery. Adv Drug Deliv Rev 2002;54 (Suppl1):S77-98.
8. Sintov AC, Shapiro L. New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo. J Control Release 2004;95:173-183.
9. Zhao X, Liu JP, Zhang X, Li Y. Enhancement of transdermal delivery of theophylline using microemulsion vehicle. Int J Pharm 2006;327:58-64.
10. Biruss B, Kählig H, Valenta C, Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones. Int J Pharm 2007;328:142-151.
11. El Maghraby GM. Transdermal delivery of hydrocortisone from eucalyptus oil microemulsion:Effects of cosurfactants. Int J Pharm 2008;355:285-292.
12. Junyaprasert VB, Boonme P, Wurster DE, Rades T. Aerosol OT microemulsions as carriers for transdermal delivery of hydrophobic and hydrophilic local anesthetics. Drug Deliv 2008;15:323-330.
13. Aggarwal N, Goindi S, Khurana R. Formulation, characterization and evaluation of an optimized microemulsion formulation of griseofulvin for topical application. J Colloid Surface B 2013;105:158-166.
14. Changez M, Varshney M, Chander J, Dinda AK. Effect of the composition of lecithin/n-propanol/isopropyl myristate/water microemulsions on barrier properties of mice skin for transdermal permeation of tetracaine hydrochloride:In vitro. J Colloid Surface B 2006;50:18-25.
15. Zhang J, Michniak-Kohn B. Investigation of microemulsion microstructures and their relationship to transdermal permeation of model drugs:Ketoprofen, lidocaine, and caffeine. Int J Pharm 2011;421:34-44.
16. Boonme P, Krauel K, Graf A, Rades T, Junyaprasert VB. Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitate/ water/ Brij 97:1-butanol. J AAPS Pharm Sci Tech 2006;7:E99-E104.
17. Golden GM, McKie JE, Potts RO. Role of stratum cornum lipid fluidity in transdermal drug flux. J Pharm Sci 1987;76:25-8.
18. Goodman M, Barry BW. Lipid-protein partitioning theory of skin enhancer activity. Finit dose technique. Int J Pharm 1989;57:29-40.
19. William AC, Barry BW. Penetration enhancer. J Adv Drug Deliv Rev 2004;5:603-618.
20. Sato K, Sugibayashi K, Morimoto Y. Effect and mode of action of aliphatic esters on the in vitro skin permeation of nicorandil. Int J Pharm 1988;43:31-40.
21. Walker RB, Smith EW. The role of percutaneous penetration enhancers. J Adv Drug Deliv Rev 1996;18:295-301.
22. Guo H, Liu Z, Li J, Nie S, Pan W. Effects of isopropyl palmitate on the skin permeation of drugs. J Biol Pharm Bull 2006;29:2324-2326.
23. Djekic L, Primorac M. The influence of cosurfactants and oils on the formation of pharmaceutical microemulsions based on PEG-8 caprylic/capric glycerides. Int J Pharm 2008;352:231-239.
24. Friberg SE. Micelies, microemulsions, liquidcrystals, and the structure of stratum corneum lipids. J Soc Cosmet Chem 1990;41:155-171.
25. O’Neil MJ, editor. The Merck Index:An encyclopedia of chemicals drugs, and biological. 14th ed. New Jersey: Merck &CO., Inc.;2006.
26. Paolino D, Ventura CA, Nistico S, Puglisi G, Fresta M. Lecithin microemulsions for the topical administration of ketoprofen: percutaneous adsorption through human skin and in vivo human skin tolerability. Int J Pharm 2002;244:21-31.
27. Alay RG, Tucker IG, Davies NM, Rades T. Characterizing colloidal structures of psuedoternary phase diagrams formed by oil/ water/amphiphiles systems. Drug Dev Ind Pharm 2001;27:31-38.
Statistics
378 Views | 1892 Downloads
How to Cite
Leesajakul, W., C. Taworn, and S. Charnnarong. “METHYL SALICYLATE MICROEMULSION BASED SYSTEMS. PART I: EFFECT OF ADDITIVES ON THE PHYSICOCHEMICAL PROPERTIES”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 7, July 2014, pp. 137-41, https://innovareacademics.in/journals/index.php/ijpps/article/view/1356.
Section
Original Article(s)