• Sunil Kumar Ravishankar College of Pharmacy, Bhopal (M.P.) India
  • D. S. Rathore NIMS Institute of Pharmacy, NIMS University, Jaipur (Rajasthan) India
  • Gopal Garg NIMS Institute of Pharmacy, NIMS University, Jaipur (Rajasthan) India
  • Kapil Khatri Ravishankar College of Pharmacy, Bhopal (M.P.) India
  • Rahul Saxena Ravishankar College of Pharmacy, Bhopal (M.P.) India
  • Sanjeev K. Sahu Ravishankar College of Pharmacy, Bhopal (M.P.) India



Diabetes, Substituted benzthiazole derivatives, Thiazolidinedione, Hypoglycemic activity


Objective: The objective of the present research investigation involves synthesis and biological evaluation of antidiabetic activity of benzothiazole derivatives.

Methods: A novel series of benzothiazole derivatives 7(a-l) were synthesised and synthesised compounds were characterised for different physical and chemical properties like molecular formula, molecular weight, melting point, percentage yield, Rf value, IR, 1HNMR, 13CNMR and mass spectroscopy. The newly synthesised benzothiazole derivatives were subsequently assayed in vivo to investigate their hypoglycemic activity by the alloxan-induced diabetic model in rats.

Results: All the synthesised derivatives showed significant biological efficacy. The compound 7d at 350 mg/kg exerted maximum glucose lowering effects whereas 7c showed minimum glucose lowering effects. All the compounds were effective, and experimental results were statistically significant at p<0.01 and p<0.05 level.

Conclusion: From the results, it is clear that compound 7d demonstrated potent anti-diabetic activity and would be of better use in drug development to combat the metabolic disorder in future.


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How to Cite

Kumar, S., D. S. Rathore, G. Garg, K. Khatri, R. Saxena, and S. K. Sahu. “SYNTHESIS AND EVALUATION OF SOME BENZOTHIAZOLE DERIVATIVES AS ANTIDIABETIC AGENTS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, no. 2, Feb. 2017, pp. 60-68, doi:10.22159/ijpps.2017v9i2.14359.



Original Article(s)