ANTI-DIARRHOEAL ACTIVITY OF CARDIOSPERMUM HALICACABUM AND DODONEA VISCOSA
Objective: The present study to carry out the anti-diarrhoeal activity of leaf extracts of Cardiospermum halicacabum and Dodonea viscosa in different experimental models of diarrhoea.
Methods: The acute toxicity of the extracts were determined, LD50was calculated according to the â€œUp and down methodâ€ following OECD guidelines No. 425 of CPCSEA. The anti-diarrhoeal potential was assessed by castor oil induced diarrhea. Gastro-intestinal motility test and Prostaglandin-E2 induced enteropooling in experimental animals.
Results: The alcoholic and aqueous extracts of Cardiospermum halicacabum and Dodonea viscosa have exhibited the dose dependant antidiarrhoeal activity in all the three experimental models by reducing the frequency of defecation as well as total weight of wet faeces, decreased the propulsion of charcoal meal through the gastrointestinal tract and also decrease in the oedema volume in the intestine (intestinal secretion) of the drug treated animals with the respective models of diarrhea.
Conclusion: Cardiospermum halicacabum and Dodonea viscosa shows to have a potential value for the development of a phytomedicine for diarrhoea. Further comprehensive chemical and pharmacological investigations are needed to elucidate the exact mechanism accountable for the exhibited activity.
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