Sushama Pawar, Manmohini Jadhav


Objective: Bacoside A is a major bioactive constituent of Bacopa monnieri L having antioxidant property. The objective of this study was to evaluate the effect of Bacoside A, on lipid peroxidation in brain, heart and liver during induced aging.

Methods: Male Swiss albino mice, Mus musculus was used for the present investigation. Four experimental groups were used as Group I-Normal adult, Group II-D-galactose induced, Group III-D-galactose induced plus Bacoside A treated and Group IV-Natural aging. The effect of Bacoside A was studied against lipid peroxidation during induced aging. The level of lipid peroxidation in the form of MDA formation was determined and measured in brain, heart and liver.

Results: The statistical data obtained were analyzed using one way ANOVA, control vs other groups and results were expressed as mean±SE. In Bacoside A treated group the lipid peroxidation level in heart, brain and liver was significantly decreased (p<0.001) compared to control group. A significant increase (p<0.0001) in the level of lipid peroxidation was observed in D-galactose induced mice. In natural aging group highly significant increase (p<0.0001) in initial lipid peroxidation, ascorbate dependent lipid peroxidation and spontaneous lipid peroxidation was observed.

Conclusion: The observations revealed that, lipid peroxidation was reversed in Bacoside A treated group which may be due to antioxidant property of Bacoside A. Thus Bacoside A is able to ameliorate the stress induced changes in lipid peroxidation during aging. The findings also provide a theoretical basis for the development of novel therapeutic formulations, such as antioxidant supplementation to boost antioxidant defenses in the body.


Oxidative stress, Aging, Lipid peroxidation, D-galactose, Bacoside A, Antioxidant

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Oxidative stress, Aging, Lipid peroxidation, D-galactose, Bacoside A, Antioxidant





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International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 9, 2017 Page: 12-15

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Authors & Affiliations

Sushama Pawar
Department of Zoology, Bharati Vidyapeeth Deemed University, Yashwantrao Mohite College of Arts, Science and Commerce, Pune 411 038, Maharashtra, India

Manmohini Jadhav
Department of Zoology, Bharati Vidyapeeth Deemed University, Yashwantrao Mohite College of Arts, Science and Commerce, Pune 411 038, Maharashtra, India

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