FORMULATION AND EVALUATION OF CEFUROXIME AXETIL SOL GEL FOR PERIODONTITS
Keywords:
Cefuroxime axetil, Pluronic F127, Thermoreversible sol gel, Cold techniqueAbstract
Objective: The objective of the present work was to formulate thermoreversible sol gel of cefuroxime axetil using Pluronic F127 and Pluronic F108. Cefuroxime axetil is a broad spectrum, second generation antibiotic used to treat various infectious diseases. Thermoreversible sol gels are shear thinning systems which show temperature dependent gelation. Once injected, the gel covers every nook and corner of the periodontal pocket thus filling it completely and is retained in the pocket.
Methods: Gels were prepared by cold technique varying the polymer concentration.
Results: The FTIR results revealed the compatibility between the drug and polymers. Drug content prior and after gelation was found to be in the range 98.8-99.8% and 98.2-99.6% respectively. The pH was in range of 6.9-7.1. The viscosity of the formulations at 250±10C and 370±10C was in the range of 530-705 cps and 1000-2100 cps respectively. The results obtained were in agreement with the phase transition. All the formulations were syringeable through 20 gauge needle. The in vitro drug release revealed a sustained profile over a period of 7 days and was found to be highest for formulation F3 i.e. 97.83%. The in vitro antimicrobial study showed promising activity of F3 against clinical isolates of P.gingivalis, E.faecalis and S.mutans. Short term stability study indicated that 40±10C is appropriate storage condition for the formulations.
Conclusion: The results indicated that the formulated sol gel can definitely be used for once a week treatment for periodontitis
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