BETAMETHASONE DIPROPIONATE GEL FOR TREATMENT OF LOCALIZED PLAQUE PSORIASIS

  • Sanaa El Gizaway Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, Egyp
  • Maha Fadel Department of Medical laser Application, National Institute of Laser Enhanced Sciences, Cairo University, Egypt
  • Basma Mourad Department of Dermatology, Andrology and Venereology Diseases, Faculty of Medicine, Tanta University
  • Fatma El-zahraa Abd Elnaby Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, Egypt

Abstract

Objective: The main aim of this study was to design and characterise betamethasone di-propionate loaded transfersomes (BD-T); as a topical formulation for the treatment of localized plaque psoriasis.

Methods: A full factorial design (23) was applied to study the effects of three independent variables: drug content, type of surfactants and surfactant contents on particle size (PS), entrapment efficiency (EE %), zeta potential (ZP), polydispersity index (PI) and drug release profiles. The optimized BD-T was formulated as a hydrogel using 5% sodium carboxymethyl cellulose. The gel was characterized for viscosity, drug content, in vitro drug release and stability. A comparative clinical study was performed on 20 patients with psoriasis to investigate the effect of BD-T gel and the marketed betamethasone dipropionate (BD) cream.

Results: The optimized BD-T formulation containing 50 mg betamethasone dipropionate (BD) and 5 mg tween 80 showed spherical unilamellar vesicles with an average particle size of 242.80, % EE of 90.19%, ZP of-15.00 mV, PI of 0.407 and K0 of 4.290 mg/hr. The formulation showed good stability at 4 °C and 25 °C for 6 mo. The results revealed significant clinical improvement and a significant increase in safety and tolerability with BD-T gel compared with BD cream.

Conclusion: As a conclusion, BD-T was found to be more effective, safe and tolerable for the treatment of psoriasis compared with the marketed product.

Keywords: Transfersomes, Betamethasone dipropionate (BD), Localized psoriasis

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Gizaway, S. E., M. Fadel, B. Mourad, and F. E.- zahraa A. Elnaby. “BETAMETHASONE DIPROPIONATE GEL FOR TREATMENT OF LOCALIZED PLAQUE PSORIASIS”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 9, no. 8, Aug. 2017, pp. 173-82, doi:10.22159/ijpps.2017v9i8.18571.
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