BETAMETHASONE DIPROPIONATE GEL FOR TREATMENT OF LOCALIZED PLAQUE PSORIASIS


Sanaa El Gizaway, Maha Fadel, Basma Mourad, Fatma El-zahraa Abd Elnaby

Abstract


Objective: The main aim of this study was to design and characterise betamethasone di-propionate loaded transfersomes (BD-T); as a topical formulation for the treatment of localized plaque psoriasis.

Methods: A full factorial design (23) was applied to study the effects of three independent variables: drug content, type of surfactants and surfactant contents on particle size (PS), entrapment efficiency (EE %), zeta potential (ZP), polydispersity index (PI) and drug release profiles. The optimized BD-T was formulated as a hydrogel using 5% sodium carboxymethyl cellulose. The gel was characterized for viscosity, drug content, in vitro drug release and stability. A comparative clinical study was performed on 20 patients with psoriasis to investigate the effect of BD-T gel and the marketed betamethasone dipropionate (BD) cream.

Results: The optimized BD-T formulation containing 50 mg betamethasone dipropionate (BD) and 5 mg tween 80 showed spherical unilamellar vesicles with an average particle size of 242.80, % EE of 90.19%, ZP of-15.00 mV, PI of 0.407 and K0 of 4.290 mg/hr. The formulation showed good stability at 4 °C and 25 °C for 6 mo. The results revealed significant clinical improvement and a significant increase in safety and tolerability with BD-T gel compared with BD cream.

Conclusion: As a conclusion, BD-T was found to be more effective, safe and tolerable for the treatment of psoriasis compared with the marketed product.


Keywords


Transfersomes, Betamethasone dipropionate (BD), Localized psoriasis

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About this article

Title

BETAMETHASONE DIPROPIONATE GEL FOR TREATMENT OF LOCALIZED PLAQUE PSORIASIS

Keywords

Transfersomes, Betamethasone dipropionate (BD), Localized psoriasis

DOI

10.22159/ijpps.2017v9i8.18571

Date

01-08-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 8, 2017 Page: 173-182

Online ISSN

0975-1491

Statistics

21 Views | 47 Downloads

Authors & Affiliations

Sanaa El Gizaway
Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, Egyp
Egypt

Maha Fadel
Department of Medical laser Application, National Institute of Laser Enhanced Sciences, Cairo University, Egypt
Egypt

Basma Mourad
Department of Dermatology, Andrology and Venereology Diseases, Faculty of Medicine, Tanta University
Egypt

Fatma El-zahraa Abd Elnaby
Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, Egypt
Egypt


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