FORMULATION AND IN VITRO EVALUATION OF COMBINED FLOATING-BIOADHESIVE TABLETS OF IMATINIB MESYLATE


Rabi Narayan Panigrahy, Susanta Kumar Panda, Prabhakar Reddy Veerareddy

Abstract


Objective: Gastro retentive drug delivery system (GRDDS) pertaining to its attributes like gastric retention time and the extended drug release profile has significantly improved patient compliance. The objective of the present study is to formulate and evaluate a stomach-specific floating-bioadhesive tablet of imatinib mesylate for prolonged residence in the stomach in the treatment of gastrointestinal stromal tumors (GIST).

Methods: All the tablets were prepared with hydroxypropylmethylcellulose (HPMC), guar gum, sodium alginate, and carbopol using direct compression technique. Physical characterization, in vitro dissolution, the mucoadhesive force along with data analysis was done on each tablet.

Results: The pre-compression characteristics of powder mixtures found to be satisfactory for all formulation batches. The results of physical evaluation for all batches were complying with pharmacopeia specification. The swelling index for all formulation batches was approximately 100% after 8 hours. The bioadhesive force (mean ± SD) reported in a range of 0.05 ± 0.09 to 0.18 ± 0.06 N/m2. It was observed that the release rate of tablets was decreased when the viscosity and concentration of the polymer were increased. Formulation batches IB1, IB2, IB4, IB5, IB6, IB9, IB10, IB11, and IB13 follows Higuchi Matrix model kinetics; whereas IB3, IB7, IB8, and IB12 follows Korsmeyer- Peppas model kinetics.

Conclusion: Formulation batch IB9 reported a considerable swelling index, floating behavior, more bioadhesive strength with uniform drug release pattern. Therefore formulation batch IB9 was selected as optimized batch and were kept for further evaluation studies.


Keywords


Gastro-retentive; Imatinib mesylate; Swelling index; Bioadhesive strength

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About this article

Title

FORMULATION AND IN VITRO EVALUATION OF COMBINED FLOATING-BIOADHESIVE TABLETS OF IMATINIB MESYLATE

Keywords

Gastro-retentive; Imatinib mesylate; Swelling index; Bioadhesive strength

DOI

10.22159/ijpps.2017v9i11.18894

Date

01-11-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 11, 2017 Page: 27-33

Online ISSN

0975-1491

Statistics

49 Views | 36 Downloads

Authors & Affiliations

Rabi Narayan Panigrahy
Department of Pharmaceutical Chemistry, Royal College of Pharmacy and Health Sciences, Andhapasara Road, Brahmapur, Odisha-760002
India

Susanta Kumar Panda
Department of Pharmaceutical Chemistry, Royal College of Pharmacy and Health Sciences, Andhapasara Road, Brahmapur, Odisha-760002
India

Prabhakar Reddy Veerareddy
Professor and Principal, College of Pharmacy, Palamuru University, Mahbubnagar, Telangana-509001
India


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