A SINGLE CASE REPORT ON HYPONATREMIA SEIZURE INDUCED BY ACETYLCHOLINESTERASE INHIBITORS


J. Shareef, J. Joseph, Adithi K.

Abstract


Donepezil and memantine are the acetylcholinesterase inhibitors most commonly used in clinical practice for the management of mild-moderate dementia in Alzheimer’s disease. Electrolyte abnormalities associated with the drugs are commonly encountered in daily clinical practice and often can lead to seizures. Hyponatremia is an uncommon adverse effects of acetylcholinesterase inhibitors. Here we present a case on hyponatremia seizure due to the syndrome of inappropriate antidiuretic hormone (SIADH) caused by the acetylcholinesterase inhibitor donepezil and memantine as other likely causes were ruled out by appropriate investigations. The causality assessment needed to be done according to Naranjo algorithm was found to be ‘probable’ and the level of severity according to the Hartwig scale was ‘Level 5’.


Keywords


Adverse drug reactions, Acetylcholinesterase inhibitors, Naranjo Algorithm, Severity level assessment

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References


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About this article

Title

A SINGLE CASE REPORT ON HYPONATREMIA SEIZURE INDUCED BY ACETYLCHOLINESTERASE INHIBITORS

Keywords

Adverse drug reactions, Acetylcholinesterase inhibitors, Naranjo Algorithm, Severity level assessment

DOI

10.22159/ijpps.2017v9i7.19057

Date

01-07-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 7, 2017 Page: 165-116

Online ISSN

0975-1491

Statistics

163 Views | 87 Downloads

Authors & Affiliations

J. Shareef
Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences, Mangaluru, Karnataka, India
India

J. Joseph
Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences, Mangaluru, Karnataka, India
India

Adithi K.
Department of General Medicine, K S Hegde Hospital, Mangaluru, Karnataka, India
India


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