DEVELOPMENT AND OPTIMIZATION OF ORODISPERSIBLE TABLETS OF CARVEDILOL BY COMBINATION OF SUPER-DISINTEGRANTS ADDITION AND SUBLIMATION TECHNIQUES


Vijayanand P., Sridevi P., Bhagavan Raju M.

Abstract


Objective: Objective of the present research work was to prepare orodispersible tablets of carvedilol (CDL) for dysphagic patients.

Methods: Carvedilol, an anti-hypertensive drug, was chosen as a model drug in this study. Orodispersible tablets of carvedilol were prepared using different super-disintegrating agents such as crospovidone, croscarmellose sodium and sodium starch glycolate at different concentrations. The best formulation was selected based on disintegration and dissolution profile that was further taken for sublimation studies using camphor, menthol and thymol. Drug-excipients interaction studies were carried out by fourier transform infra-red (FTIR) spectrophotometer with pure drug sample and optimized formulation.

Results: The orodispersible tablet formulation having 4% croscarmellose sodium disintegrated in 92 sec. Hence this formulation was considered best formulation and taken further for sublimation studies. A formulation containing 10% w/w of menthol showed disintegration time of 16 sec with more than 96.64% drug release within 15 min. Menthol leaves the porous structure as it sublimates from the tablet. This might have contributed to the decrease in disintegration time. Hence, this formulation was considered optimized.

Conclusion: From this study, it can be concluded that orodispersible tablets of carvedilol may prove to be more efficacious in the treatment of hypertension particularly in dysphagic patients.


Keywords


Orodispersible tablets, Super-disintegrants, Sublimation, Carvedilol, Anti-hypertensive

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About this article

Title

DEVELOPMENT AND OPTIMIZATION OF ORODISPERSIBLE TABLETS OF CARVEDILOL BY COMBINATION OF SUPER-DISINTEGRANTS ADDITION AND SUBLIMATION TECHNIQUES

Keywords

Orodispersible tablets, Super-disintegrants, Sublimation, Carvedilol, Anti-hypertensive

DOI

10.22159/ijpps.2017v9i7.19161

Date

01-07-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 7, 2017 Page: 155-160

Online ISSN

0975-1491

Statistics

64 Views | 52 Downloads

Authors & Affiliations

Vijayanand P.
Sri Venkateshwara College of Pharmacy, Madhapur, Hyderabad 500081, India
India

Sridevi P.
Sri Venkateshwara College of Pharmacy, Madhapur, Hyderabad 500081, India
India

Bhagavan Raju M.
Sri Venkateshwara College of Pharmacy, Madhapur, Hyderabad 500081, India


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