NANOCRYSTAL SUSPENSION OF CEFIXIME TRIHYDRATE PREPARATION BY HIGH-PRESSURE HOMOGENIZATION FORMULATION DESIGN USING 23 FACTORIAL DESIGN


Rajveer Bhaskar, Prakash Hiraman Patil

Abstract


Objective: In the present study, nanocrystal suspensions of cefixime trihydrate were prepared with the objective of providing increased solubility and stability with their nanoscopic size and thus developing the formulation of enhanced bioavailability potential.

Methods: Nanocrystal suspensions were prepared by high-pressure homogenization technique using PVP K-30 as a stabilizer and evaluated for particle size, polydispersity index, zeta potential, permeation and drug release.

Results: Particles of average size 143.5 nm having a polydispersity index of 0.269 were produced. Zeta potential was found to be −36.6 mV and the formulation was found stable on the basis of results obtained from differential scanning calorimetry and Fourier transform infrared spectroscopy studies. Optimized formulation showed 89.79 % and 88.38% drug lease and permeation respectively.

Conclusion: The drug release and ex-vivo permeation studies revealed enhanced permeation of drug, as desired, indicating its potential for an attempt towards successful nano crystal formulation.


Keywords


Nanocrystal suspension, Cefixime trihydrate, High-pressure homogenization, Drug release

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About this article

Title

NANOCRYSTAL SUSPENSION OF CEFIXIME TRIHYDRATE PREPARATION BY HIGH-PRESSURE HOMOGENIZATION FORMULATION DESIGN USING 23 FACTORIAL DESIGN

Keywords

Nanocrystal suspension, Cefixime trihydrate, High-pressure homogenization, Drug release

DOI

10.22159/ijpps.2017v9i9.19319

Date

13-07-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 9, 2017 Page: 64-71

Online ISSN

0975-1491

Statistics

49 Views | 59 Downloads

Authors & Affiliations

Rajveer Bhaskar
Department of Pharmaceutics and Quality Assurance, R C Patel Institute of Pharmaceutical Education & Research, Near Karvand Naka, Shirpur, District- Dhule, Maharashtra 425405
India

Prakash Hiraman Patil
Department of Pharmaceutics and Quality Assurance, R C Patel Institute of Pharmaceutical Education & Research, Near Karvand Naka, Shirpur, District- Dhule, Maharashtra 425405


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