MODEL AND RELEASE PATTERN OF WATER SOLUBLE DRUG FROM NATURAL-POLYMER BASED SUSTAINED RELEASE TABLET DOSAGE FORM
Objective: The aim of this research was to investigate and evaluate the drug release characteristics (models and drug release profiles) using natural polymers (pectin, carrageenan and glucomannan) in water soluble drug of sustained release tablet.
Methods: Captopril was used as drug model. Tablet were prepared using wet granulation method. Pectin, carrageenan and glucomannan were used as matrix with concentration 20%, 30% and 40%" with "matrices with various concentration. Physyical properties inpections were conducted on granules and tablets. Dissolution test using apparatus II USP model with 50 rpm of speed rotation, 900 ml of HCl 0.1N as medium. The results were analyzed statistically by MANOVA, dependent model and independent model.
Results: The results showed that enhancement of matrix concentrations decreased the fluidity and compact-ability. Drug release of soluble drug using pectin as matrix not significant different than without matrix.
Conclusion: Tablet using glucomannan and carrageenan as matrix controlled the drug release with initial burst release effect. Weibull models was the best fitting model of release kinetics with the highest coefficient of determination and similarity between predicted and observed data Â and the release mechanisms were controlled by anomalous transport.
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