CORRELATION BETWEEN PLASMA TAMOXIFEN CONCENTRATION AND TUMOR RESPONSE IN PATIENTS WITH BREAST CANCER: AT NEOADJUVANT TREATMENT WITH TAMOXIFEN


Bruno Jose Dumet Fernandes, Angelo Do Carmo Silva Matthes, Sergio Bighetti, Juliana Dumet Fernandes, Vera Lucia Lanchote, Catharina Rodrigues Pinto Lopes

Abstract


Objective: to determine a possible correlation between the tumor response in patients suffering from breast cancer, initially treated with tamoxifen, and plasma concentration of this drug.

Methods: we studied 27 elderly patients (age range: 62 to 82 y) with advanced breast carcinoma who were treated with a daily dose of 20 mg of oral tamoxifen, for 3 mo. Responders were followed-up for 19 mo, and nonresponders for 21 mo. We measured plasma tamoxifen citrate levels in order to determine their possible correlation with objective remission of the disease.

Results: the correlation was found to be significant among responders (37%), whose median plasma tamoxifen level was 187.40ng. ml-1, when comparing to non-responders, whose median plasma tamoxifen level was 99.52ng. ml-1. The frequency distribution of patients in both groups with concentration of tamoxifen lower and higher than 182.60ng. ml-1 was significant (fisher’s test p-value<0,0011).

Conclusion: considering the results herein, we suggest that patients whose plasma tamoxifen levels reach 182.60ng. ml-1 after 3 mo of treatment, with no tumor response, may not benefit from this treatment, and an alternative therapy should be regarded.


Keywords


Breast cancer, Tumor response, Plasma tamoxifen, Neoadjuvant

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About this article

Title

CORRELATION BETWEEN PLASMA TAMOXIFEN CONCENTRATION AND TUMOR RESPONSE IN PATIENTS WITH BREAST CANCER: AT NEOADJUVANT TREATMENT WITH TAMOXIFEN

Keywords

Breast cancer, Tumor response, Plasma tamoxifen, Neoadjuvant

DOI

10.22159/ijpps.2017v9i9.19460

Date

13-07-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 9, 2017 Page: 100-106

Online ISSN

0975-1491

Statistics

34 Views | 24 Downloads

Authors & Affiliations

Bruno Jose Dumet Fernandes
Department of Clinical Analysis and Toxicology, Faculty of Pharmacy, Federal University of Bahia, Salvador, BA, Brazil
Brazil

Angelo Do Carmo Silva Matthes
Department of Obstetrics and Gynecologic of Clinical Hospital of Faculty of Medicine of Ribeirão Preto, University of São Paulo, SP, Brazil
Brazil

Sergio Bighetti
Department of Obstetrics and Gynecologic of Clinical Hospital of Faculty of Medicine of Ribeirão Preto, University of São Paulo, SP, Brazil
Brazil

Juliana Dumet Fernandes
Department of Dermatology, Clinical Hospital Prof. Edgard Santos, Federal University of Bahia, Salvador, BA, Brazil
Brazil

Vera Lucia Lanchote
Department of Toxicology, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil
Brazil

Catharina Rodrigues Pinto Lopes
Department of Dermatology, Clinical Hospital Prof. Edgard Santos, Federal University of Bahia, Salvador, BA, Brazil
Brazil


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