Novie E. Mauliku, Hendro W., Suharyo Hadi Saputro, Tri N. Kristina


Objective: This study aimed to evaluate the antitubercular activity of extracts and compounds isolated of Morinda citrofolia Linn (noni) against Mycobacterium tuberculosis strains (H37Rv) with a dose of 10 mg/ml, 20 mg/ml, 30 mg/ml and 40 mg/ml.


Methods: The noni fruits was extracted using 96% ethanol. A crude ethanol extract of noni tested by phytochemical fractionation to obtain flavonoids, alkaloids, scopoletin, and anthraquinone. Extract and active compounds of noni testing antibacterial activity against tuberculosis (H37RV) bacterial with a dose of 10 mg / ml, 20 mg / ml, 30 mg / ml and 40 mg / ml. This study was performed in vitro with laboratory-based experimental study. Statistical analysis was performed by analysis of variance.

Results: Compounds of noni shown to have antitubercular activity in inhibiting the growth of MDR TB bacteria at various doses compared to controls (p = 0.00). The mean number of bacterial colonies on the MDR TB crude ethanol extract (59.0± 60.51), alkaloids (64.8 ± 49.36), anthraquinone (69.5 ± 50.40), flavonoids (72.9 ± 58.7), scopoletin (95.9 ± 33.3) and negative controls (189.3 ± 35.19). Crude extract, alkaloids, anthraquinones, and flavonoid have highly bactericidal inhibition than scopoletin and negative control. The exhibited minimum inhibitory concentration (MIC) against M. Tuberculosis on the compound of the noni fruit is at a dose of 40 mg / ml

 Conclusion: All compounds and extract of noni fruits represents a potent active anti-TB against M. tuberculosis strains. An crude extract of  noni was the most active compound against M. tuberculosis strains (H37RV).



Morinda citrifolia Linn., Anti-tubercular activity, Flavonoids, Scopoletin, Alkaloids, Anthraquinones

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Morinda citrifolia Linn., Anti-tubercular activity, Flavonoids, Scopoletin, Alkaloids, Anthraquinones





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International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 12, 2017 Page: 105-109

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Authors & Affiliations

Novie E. Mauliku
Doctoral Program of Medical and Health Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia, 50241

Hendro W.
Doctoral Program of Medical and Health Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia, 50241

Suharyo Hadi Saputro
Doctoral Program of Medical and Health Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia, 50241

Tri N. Kristina
Doctoral Program of Medical and Health Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia, 50241

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