• CHINNASAMY RAJARAM PRAKASH Department of Medicinal Chemistry, DCRM Pharmacy College, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, India
  • Sundararajan Raja Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, Andhra Pradesh, India
  • Govidaraj Saravanan Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla- 522 101, Andhra Pradesh, India.


Schiff bases, Mannich Bases, Isatin, Anti-epileptic Activity


Objective: Synthesis and anti-epileptic evaluation of some novel Schiff and Mannich bases of isatin derivatives.

Methods: A series of novel 3-(4-(4-(substituted benzylideneamino)-5-mercapto-4-1,2,4-triazole-3-yl)phenylimino)-1-((dimethyl amino) methyl)-5-fluoroindolin-2-one Schiff and Mannich base derivatives were synthesized by using various aromatic aldehydes with isatin derivatives. The chemical structures of all synthesized compounds were confirmed by IR, 1H-NMR, Mass spectra and elemental analysis. All the synthesized compounds were screened for its anti-epileptic activity by MES and scPTZ methods using Phenytoin and Ethosuximide as standards.

Results: The results of anti-epileptic activity showed that some of the synthesized compounds were exhibited significant results.

Conclusion: This investigation identified the potent anti-epileptic agents and these molecules will be subjected to further studies in our laboratory.


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How to Cite

PRAKASH, C. R., S. Raja, and G. Saravanan. “SYNTHESIS AND ANTI-EPILEPTIC ACTIVITY OF SOME NOVEL 3-(4-(4-(SUBSTITUTED BENZYLIDENEAMINO)-5-MERCAPTO-4-1,2,4-TRIAZOLE-3-YL)PHENYLIMINO)-1-((DIMETHYL AMINO) METHYL)-5-FLUOROINDOLIN-2-ONE DERIVATIVES”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 539-44,



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