ANTIOXIDANT EFFECT OF POLYHERBAL FORMULATION IN ISOPRENALINE HYDROCHLORIDE INDUCED MYOCARDIAL INFARCTION IN RATS


Kavitha P., Sowmia C.

Abstract


Objective: Myocardial infarction (MI) continues to be a major public health problem in the world. The prepared polyherbal formulation (PHF) exhibit cardioprotective effects by several mechanisms. The objective of the research was to evaluate the antioxidant effect of a polyherbal formulation in isoprenaline hydrochloride (ISO) induced myocardial infarction in rats.

Methods: Oxidative stress and myocardial infarction was induced by administration of isoprenaline hydrochloride (25 mg/kg) for 2 d. The degree of protection was determined by measuring the levels of lipid peroxidation (LPO), enzymatic antioxidants (superoxide dismutase-SOD, Catalase, Glutathione peroxidase) and non-enzymatic antioxidants (Vitamin C, E and reduced glutathione-GSH).

Results: Two different doses (250 mg and 500 mg/kg body wt) of the formulation was used to prove the cardioprotective effect. Pretreatment with polyherbal formulation significantly (P<0.05) lowered LPO and elevated the enzymatic and non-enzymatic antioxidants in heart homogenate.

Conclusion: The polyherbal formulation exhibited cardioprotective activity, which could be attributed to its antioxidant activity.

 


Keywords


Myocardial infarction, Polyherbal formulation, Isoprenaline hydrochloride, Oxidative stress, Free radicals

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About this article

Title

ANTIOXIDANT EFFECT OF POLYHERBAL FORMULATION IN ISOPRENALINE HYDROCHLORIDE INDUCED MYOCARDIAL INFARCTION IN RATS

Keywords

Myocardial infarction, Polyherbal formulation, Isoprenaline hydrochloride, Oxidative stress, Free radicals

DOI

10.22159/ijpps.2017v9i10.20310

Date

02-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol. 9, Issue 10, 2017 Page: 273-275

Online ISSN

0975-1491

Statistics

45 Views | 30 Downloads

Authors & Affiliations

Kavitha P.
G and Research Department of Biochemistry, Dr.NGP Arts and Science College, Coimbatore, Tamilnadu 641048, India
India

Sowmia C.
PG and Research Department of Biochemistry, Dr.NGP Arts and Science College, Coimbatore, Tamilnadu 641048, India


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