SEARCH FOR NEW ANTILEISHMANIAL CHEMOTHERAPEUTICS


Nabanita Kar, Santanu Ghosh, Leena Kumari, Shreyasi Chakraborty, Tanmoy Bera

Abstract


Objective: The objective of this work was to screen a number of compounds for their antileishmanial efficacy and cytotoxicity profiling.

Methods: Curry leaf oil, cypress oil and spikenard oil were identified by gas chromatography-mass spectrometry (GC/MS) analysis. Betulinic acid, spikenard oil, cypress oil and curry leaf oil were evaluated for their in vitro antileishmanial activity against Leishmania donovani AG83 wild-type, sodium stibogluconate resistant (SSG-resistant), paromomycin (PMM-resistant) and GE1 field type strains on axenic and cellular amastigote model and compared the results with standard drugs used to treat leishmaniasis.

Results: Betulinic acid showed strong antileishmanial activity against wild-type (SI= 192.8), SSG-resistant (SI= 19.3) and GE1 strains (SI= 100), whereas cypress oil has produced highest antileishmanial activity against PMM-resistant strains (SI= 15.09) among all the tested drugs. The data obtained also revealed that cypress oil had the maximum CC50 value of 452.9 μl among all standard and tested drugs.

Conclusion: All tested drugs had antileishmanial property but among them, betulinic acid possess strong antileishmanial activity in case of both wild-type and drug-resistant leishmaniasis.


Keywords


Betulinic acid, Spikenard oil, Cypress oil, Curry leaf oil, GC/MS, In vitro antileishmanial activity

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About this article

Title

SEARCH FOR NEW ANTILEISHMANIAL CHEMOTHERAPEUTICS

Keywords

Betulinic acid, Spikenard oil, Cypress oil, Curry leaf oil, GC/MS, In vitro antileishmanial activity

DOI

10.22159/ijpps.2018v10i1.20859

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 1, 2018 Page: 46-52

Online ISSN

0975-1491

Statistics

130 Views | 130 Downloads

Authors & Affiliations

Nabanita Kar
Laboratory of Nanomedicine, Division of Pharmaceutical Biotechnology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
India

Santanu Ghosh
Laboratory of Nanomedicine, Division of Pharmaceutical Biotechnology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
India

Leena Kumari
Laboratory of Nanomedicine, Division of Pharmaceutical Biotechnology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
India

Shreyasi Chakraborty
Laboratory of Nanomedicine, Division of Pharmaceutical Biotechnology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
India

Tanmoy Bera
Laboratory of Nanomedicine, Division of Pharmaceutical Biotechnology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
India


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