ASSOCIATION OF PATIENT RELATED RISKFACTORS WITH EFFECTIVENESS OF PALLIATIVE CHEMOTHERAPY IN CANCER PATIENTS
Keywords:Risk factors, Chemotherapy, Adverse drug reactions, Response evaluation criteria in solid tumours
Objective: To assess the association of some risk factors on the effectiveness of palliative chemotherapy treatment in cancer patients.
Methods: A prospective observational study was conducted in the department of radiotherapy for a period of 6 mo. Ages, Gender, Cancer type, Physical Functioning, Anxiety and Depression, Medical Social Support, Comorbidities, Adverse Drug Reactions are defined as risk factors. The effectiveness of palliative chemotherapy treatment was defined according to Response Evaluation Criteria in Solid Tumors (RECIST). Mean and standard deviation was calculated from the age. The association between risk factors and the effectiveness of chemotherapy treatment was found by chi-square test. The level of significance was taken as p<0.05.
Results: The association between risk factors and effectiveness of palliative chemotherapy treatment was found using Chi-Square test. The mean age of patients in the present study was 50.57Â±12.62 y. Females were more commonly affected. The Majority of the patients were illiterate, married and homemaker. Reproductive system related cancers (50.66%) were more predominant in the present study. A statistically significant association was observed between age (p=0.027), physical functioning (p=0.0076), anxiety (p=0.000072) and depression (p=0.000016), co-morbidities (p<0.00001) and adverse drug reactions (p<0.00001) with effectiveness of chemotherapy treatment.
Conclusion: By predicting these risk factors prior to the initiation of treatment, we can minimize their unfavourable effect on the effectiveness of treatment.
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