SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY OF NOVEL N-PHENYLPROPYL-3-SUBSTITUTED INDOLINE-2-ONE DERIVATIVES


Pushpa ., Basavaraj S. Naraboli, J. S. Biradar

Abstract


Objective: The objective of the present work deals with the synthesis, characterization and evaluation of antimicrobial and antioxidant activity of N-phenylpropyl-3-substituted indoline-2-one derivatives.

Methods: A series of new 3-hydroxy-3-(2-oxoethyl)-1-(3-phenylpropyl) indolin-2-one derivatives 3(a-l) and 3-(2-oxoethylidene)-1-(3-phenylpropyl) indolin-2-one derivatives 4(a-l) were synthesized by knoevenagel condensation of N-phenylpropyl–5-substituted indole-2,3-diones with various acetophenones analogues. The chemical structures of synthesized compounds were confirmed by IR, 1HNMR and Mass spectroscopic and elemental data. These compounds were also screened for their in vitro antimicrobial and antioxidant activities.

Results: Novel compounds 3-hydroxy-3-(2-oxoethyl)-1-(3-phenylpropyl) indolin-2-one derivatives 3(a-l) and 3-(2-oxoethylidene)-1-(3-phenylpropyl) indolin-2-one derivatives 4(a-l) were synthesised and characterized using spectral and analytical data. The results of antibacterial and antifungal and antioxidant activities showed that some of the synthesized compounds exhibited promising results.

Conclusion: All the newly synthesized compounds were screened for antimicrobial activity by cup plate method and antioxidant activity by the DPPH method using Ciprofloxacin and Amphotericin B as standards against gram positive and gram negative bacteria and fungi respectively.


Keywords


Indole-2,3-diones, Pyridine, Thiophene, Antimicrobial, Antioxidant

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About this article

Title

SYNTHESIS, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY OF NOVEL N-PHENYLPROPYL-3-SUBSTITUTED INDOLINE-2-ONE DERIVATIVES

Keywords

Indole-2,3-diones, Pyridine, Thiophene, Antimicrobial, Antioxidant

DOI

10.22159/ijpps.2017v9i10.21083

Date

02-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol. 9, Issue 10, 2017 Page: 165-170

Online ISSN

0975-1491

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Authors & Affiliations

Pushpa .
Department of Studies and Research in Chemistry, Gulbarga University, Kalaburagi -585106, Karnataka, India
India

Basavaraj S. Naraboli
Department of Studies and Research in Chemistry, Gulbarga University, Kalaburagi -585106, Karnataka, India
India

J. S. Biradar
Department of Studies and Research in Chemistry, Gulbarga University, Kalaburagi -585106, Karnataka, India


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