HYPOCHOLESTEROLEMIC EFFECT AND PIGMENTS COMPOSITION OF HERBAL MEDICINE CONTAINING HIGHER AND LOWER PLANTS


Leenawaty Limantara, Renny Indrawati, Dian Ekawati Wijaya, Erni Sulistiawati, Irma Herawati Suparto, Retno Dumilah Esti Wijayanti, Tatas Hardo Panintingjati Brotosudarmo

Abstract


Objective: The objective of this research was to investigate the antihypercholesterolemic activity of herbal medicine which consisted of pigment-rich simplicia from higher and lower plants, as well as to determine its pigments composition.

Methods: Sprague-Dawley male rats were randomly divided into five cholesterol-rich diet groups as well as one negative control group with a normal diet, in order to investigate its effect on plasma lipid. The new herbal formulation was administered orally to induced-rats at three dosage levels, whereas simvastatin was used as a comparable generic drug. Pigments composition was determined by means of reversed-phase high-performance liquid chromatography (HPLC) using gradient protocol, monitored with diode array detector at 430 nm.

Results: The administration of herbal medicine was able to significantly reduce total plasma cholesterol and low-density lipoprotein-cholesterol (p<0.05) at a dose of 312.5 mg/kg of body weight/day compared to positive control group, and hence the atherogenic index was also lowered. The chromatographic analysis of pigments determination and quantification are reported correspondingly to support the possible active compounds data of hypocholesterolemic property.

Conclusion: The results obtained in this research work indicated the potency of pigment-rich lower plants to substitute the obtrusive exploration and dominant use of higher plants for treating dyslipidemia. 


Keywords


Herbal medicine, Lower plants, pigments, Cholesterol, Rats

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About this article

Title

HYPOCHOLESTEROLEMIC EFFECT AND PIGMENTS COMPOSITION OF HERBAL MEDICINE CONTAINING HIGHER AND LOWER PLANTS

Keywords

Herbal medicine, Lower plants, pigments, Cholesterol, Rats

DOI

10.22159/ijpps.2017v9i11.21133

Date

01-11-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 11, 2017 Page: 97-103

Online ISSN

0975-1491

Statistics

30 Views | 14 Downloads

Authors & Affiliations

Leenawaty Limantara
Ma Chung Research Center for Photosynthetic Pigments, Universitas Ma Chung, Malang, Indonesia
Indonesia

Renny Indrawati
Chemistry Study Program, Faculty of Sains and Technology, Universitas Ma Chung, Malang, Indonesia
Indonesia

Dian Ekawati Wijaya
Ma Chung Research Center for Photosynthetic Pigments, Universitas Ma Chung, Malang, Indonesia
Indonesia

Erni Sulistiawati
Primate Research Center, Bogor Agricultural University, Bogor, Indonesia
Indonesia

Irma Herawati Suparto
Primate Research Center, Bogor Agricultural University, Bogor, Indonesia
Indonesia

Retno Dumilah Esti Wijayanti
Agency for the Assessment and Application of Technology, LAPTIAB-BPPT, Serpong, Indonesia
Indonesia

Tatas Hardo Panintingjati Brotosudarmo
Ma Chung Research Center for Photosynthetic Pigments, Universitas Ma Chung, Malang, Indonesia


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