DIFFERENCE OF TUMOR MASS IN STADIUM IIB-IIIB SQUAMOUS CELL CERVICAL CANCER PATIENTS WHO UNDERWENT PACLITAXEL CISPLATIN AND PACLITAXEL CARBOPLATIN CHEMOTHERAPY AT SANGLAH HOSPITAL DENPASAR


Rini Noviyani, Putu Ayu Indrayathi, I. Nyoman Gede Budiana, Ketut Suwiyoga, Septiara Putri

Abstract


Objective: One of the parameters to measure the efficacy of the use of platinum based chemotherapy was the difference of tumor mass. Unfortunately, there was limited data about the use of rational chemotherapy medicine for cervical cancer patients at Sanglah Hospital. Therefore, research to find more data about the difference of tumor mass was necessary.  

Method: A prospective observational research conducted at Sanglah Hospital from January until August 2016 by using consecutive sampling method. Patients qualified for the inclusive criteria were separated into two groups, paclitaxel cisplatin and paclitaxel carboplatin. Tumor mass data was gathered from before chemotherapy I and after chemotherapy VI by using USG 2D LOGIQ V5. Data analysed was performed with SPSS 20.0 for windows with a 95% confidence level using Wilcoxon test and Mann Whitney test.

Result: The mean value of tumor mass for patients in paclitaxel cisplatin regimen group before chemotherapy I and after chemotherapy VI were 68.91+7.41 cm3 and 10.62+6.82 cm3 respectively (p value=0.018). The mean value of tumor mass for patients in paclitaxel carboplatin regimen group before chemotherapy I and after chemotherapy VI were 53.44+52.25 cm3 and 9.18 + 8.23 cm3 respectively (p value=0.007). Meanwhile, the mean value of difference in tumor mass in paclitaxel cisplatin and paclitaxel carboplatin group was -58.29 + 49.93 cm3 and -44.26 + 51.48 cm3 respectively (p value=0.242).        

Conclusion: This research shows that there was a significant difference of tumor mass before chemotherapy I and chemotherapy VI in both regimen groups. There was a bigger decrease of tumor mass in patients from paclitaxel cisplatin chemotherapy group compared to paclitaxel carboplatin group, but not significantly different. 


Keywords


Tumor mass; Cervical cancer; Chemotherapy; Paclitaxel cisplatin; Paclitaxel carboplatin.

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About this article

Title

DIFFERENCE OF TUMOR MASS IN STADIUM IIB-IIIB SQUAMOUS CELL CERVICAL CANCER PATIENTS WHO UNDERWENT PACLITAXEL CISPLATIN AND PACLITAXEL CARBOPLATIN CHEMOTHERAPY AT SANGLAH HOSPITAL DENPASAR

Keywords

Tumor mass; Cervical cancer; Chemotherapy; Paclitaxel cisplatin; Paclitaxel carboplatin.

DOI

10.22159/ijpps.2017v9i11.21375

Date

01-11-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 11, 2017 Page: 139-143

Online ISSN

0975-1491

Statistics

40 Views | 16 Downloads

Authors & Affiliations

Rini Noviyani
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Udayana University, Postal Code 80361, Bali, Indonesia
Indonesia

Putu Ayu Indrayathi
Program Study of Public Health, Faculty of Medicine, Udayana University, Postal Code 80234, Bali, Indonesia
Indonesia

I. Nyoman Gede Budiana
Department Obstetrics and Gynecology, Faculty of Medicine, University of Udayana, Postal Code 80234, Bali, Indonesia
Indonesia

Ketut Suwiyoga
Department Obstetrics and Gynecology, Faculty of Medicine, University of Udayana, Postal Code 80234, Bali, Indonesia
Indonesia

Septiara Putri
Centre for Health Economics and Policy Studies, Faculty of Public Health, University of Indonesia, Postal Code 16424, Jakarta, Indonesia
Indonesia


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