BEHAVIORAL STUDIES OF WISTAR RATS IN ROTENONE INDUCED MODEL OF PARKINSON’S DISEASE


Srimathi Priyanga K., Vijayalakshmi K., Selvaraj R.

Abstract


Objective: The objective of the study was to determine the behavioral activities of Wistar rats induced with rotenone.

Methods: Thirty-six male Wistar rats were taken for the study and divided into six groups of six rats each. Group-I is the vehicle-treated, Group–II animals were induced with rotenone (3 mg/kg/bwt) by i. p. Group-III were co-treated with rotenone and L-DOPA (10 mg/kg/bwt) orally, Group-IV were co-treated with rotenone and quercetin (25 mg/kg/bwt) orally, Group-V were co-treated with rotenone and hesperidin (50 mg/kg/bwt) orally, Group-VI were treated with rotenone, quercetin and hesperidin in the same dosage regime for 60 d. The behavioural tests, such as open field test, ladder climbing test and hanging wire test were performed. The biochemical parameters such as urea, creatinine and activities of ALT and AST were also analysed.

Results: All data are expressed as the mean±SD. Disability was noted in the behaviour of rats induced with Parkinson’s disease (PD). The deficits in behavioral activity were significantly changed when compared with an induced group (p<0.001) and biochemical parameters due to rotenone were significantly (p<0.001) restored by co-treatment with quercetin and hesperidin.

Conclusion: In our in vivo study, we have demonstrated the combination of quercetin and hesperidin to serve as neuroprotective compounds by improving the behavioral abnormalities and restoring the biochemical parameters. Hence, these powerful antioxidants may protect brain cells.


Keywords


Rotenone, Parkinson’s disease, Quercetin, Hesperidin, L-DOPA, Behavioural study, Biochemical parameters

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About this article

Title

BEHAVIORAL STUDIES OF WISTAR RATS IN ROTENONE INDUCED MODEL OF PARKINSON’S DISEASE

Keywords

Rotenone, Parkinson’s disease, Quercetin, Hesperidin, L-DOPA, Behavioural study, Biochemical parameters

DOI

10.22159/ijpps.2017v9i11.21465

Date

01-11-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 11, 2017 Page: 159-164

Online ISSN

0975-1491

Statistics

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Authors & Affiliations

Srimathi Priyanga K.
Department of Biochemistry, Bharathi Women’s college

Vijayalakshmi K.
Department of Biochemistry, Bharathi Women’s college

Selvaraj R.
Scientist ‘E’ Centre for Laboratory Animal Technology and Research, Sathyabama University


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