PROTECTIVE APTITUDE OF BORASSUS FLABELLIFER ROOT EXTRACTS AGAINST PARACETAMOL-INDUCED LIVER TOXICITY AND MYCOBACTERIUM TUBERCULOSIS (H37 RV)


Veda Priya Gummadi, Mallikarjuna Rao Talluri, Keerthana Diyya, Ganga Rao Battu

Abstract


Objective: Borassus flabellifer is an doub palm tree, different parts of it have been using as food and in traditional medicine. The root parts (rhizomes) are used for phytochemical analysis and evaluation of hepatoprotective and anti-tuberculosis activities.

Materials: Hepatoprotective activity of Borassus flabellifer root extracts were studied on paracetamol-induced liver toxicity in rats and anti-tuberculosis activity on Mycobacterium tuberculosis [H37 Rv strain] quantitative determination using Microplate Alamar Blue assay (MABA) method.

Results: The phytochemical analysis of different extracts B. flabellifer roots showed the presence of sterols, terpenoids, glycosides, carbohydrates, proteins, flavanoids, alkaloids, phenols, tannins, saponins and oils. The methanolic extract showed more phenolic and alkaloid contents on their quantification. Ethyl Acetate, Chloroform and Methanol extracts of B. flabellifer showed the dose dependent percentage protection of on paracetamol-induced liver toxicity. The methanol extract showed more activity and is comparable with standard drug Liv 52 on altered liver biomarker enzymes AST (SGOT), ALT (SGPT), ALP, total bilirubin and total protein levels with percentage protection 70.58%, 68.91%, 69.30% 71.18% and 70.73%. The ethyl acetate extract showed more anti-tuberculosis activity than methanol extract with MIC 6.25μg/mL but the extracts showed lower activity compared to standard drugs ciprofloxacin, Streptomycin and pyrazinamide of the MIC values are 6.25, 3.125, 3.125 μg/mL.

Conclusion: B. flabellifer roots posses different phytochemical constituents and those extracts posses hepatoprotective and anti-tuberculosis activities

 


Keywords


Borassus flabellifer; Roots; Paracetamol; Liver; Tuberculosis

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About this article

Title

PROTECTIVE APTITUDE OF BORASSUS FLABELLIFER ROOT EXTRACTS AGAINST PARACETAMOL-INDUCED LIVER TOXICITY AND MYCOBACTERIUM TUBERCULOSIS (H37 RV)

Keywords

Borassus flabellifer; Roots; Paracetamol; Liver; Tuberculosis

DOI

10.22159/ijpps.2017v9i12.21692

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 12, 2017 Page: 206-211

Online ISSN

0975-1491

Statistics

20 Views | 4 Downloads

Authors & Affiliations

Veda Priya Gummadi
AU College of Pharmaceutical Science, Andhra University, Visakhapatnam, Andhra Pradesh-530003
India

Mallikarjuna Rao Talluri
AnaCipher Clinical Research Organization, Ramanthapur, Hyderabad, Telangana 500013

Keerthana Diyya
AU College of Pharmaceutical Science, Andhra University, Visakhapatnam, Andhra Pradesh-530003

Ganga Rao Battu
AU College of Pharmaceutical Science, Andhra University, Visakhapatnam, Andhra Pradesh-530003


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