EFFECTS OF AQUEOUS STEM BARK EXTRACT OF XYLOPIA AETHIOPICA ON THE REPRODUCTIVE FUNCTIONS OF MALE RATS


Cyprien Magloire Hambe, Marie Ngaha Njila, Hubert Kenmogne, Brice Landry Koloko, Dieudonne Massoma Lembe

Abstract


Objective: The sexual stimulatory effect of aqueous stem bark extract of Xylopia aethiopica which is commonly used traditionally for the treatment of fertility-related problems in males is reported in this work.

Methods: The present study investigated the effect of 14 d oral administration of 1 ml/kg distilled water (control), 100, 200 and 300 mg/kg of body weight of the stem bark extract on some fertility parameters of the Swiss male rats. So, all the target organs (testis, epididymis, vas deferens, seminal vesicle and prostate) were weighed. The sperm motility and sperm count in testis, epididymis and vas deferens were determined. Serum and tissue protein, as well as cholesterol, were evaluated. The serum testosterone level was also assessed.

Results: The extract did not produced significant change in the mobility of sperm, the sperm count in vas deferens, the relative weight of body and accessory organs at all doses. The daily sperm production (DSP) and the weight of prostate significantly increased at a dose of 100 mg/kg (p<0.01) while the sperm count in cauda epididymis increased at a dose of 200 mg/kg. The testicular and serum cholesterol significantly increased (p<0.001) at the dose of 100 mg/kg whereas the testicular and serum proteins increased (p<0.001) at the dose of 200 mg/kg. The serum testosterone level increased following 14 d of treatment (p<0.01) at the dose of 100 mg/kg.

Conclusion: The results suggest that Xylopia aethiopica may have the potentials of being developed into a male fertility enhancing drug.


Keywords


Spermatogenesis, Xylopia aethiopica, Testosterone level, Fertility

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References


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About this article

Title

EFFECTS OF AQUEOUS STEM BARK EXTRACT OF XYLOPIA AETHIOPICA ON THE REPRODUCTIVE FUNCTIONS OF MALE RATS

Keywords

Spermatogenesis, Xylopia aethiopica, Testosterone level, Fertility

DOI

10.22159/ijpps.2018v10i1.22038

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 1, 2018 Page: 113-117

Online ISSN

0975-1491

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Authors & Affiliations

Cyprien Magloire Hambe
Department of Animal Sciences, Faculty of Science, University of Douala, 24157 Douala, Cameroon
Cameroon

Marie Ngaha Njila
Department of Animal Sciences, Faculty of Science, University of Douala, 24157 Douala, Cameroon
Cameroon

Hubert Kenmogne
Department of Animal Sciences, Faculty of Science, University of Douala, 24157 Douala, Cameroon
Cameroon

Brice Landry Koloko
Department of Animal Sciences, Faculty of Science, University of Douala, 24157 Douala, Cameroon
Cameroon

Dieudonne Massoma Lembe
Department of Animal Sciences, Faculty of Science, University of Douala, 24157 Douala, Cameroon
Cameroon


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