PHOTODEGRADATION OF 1, 4-DIHYDROPYRIDINE ANTIHYPERTENSIVE DRUGS: AN UPDATED REVIEW


Michele De Luca, Giuseppina Ioele, Claudia Spatari, Gaetano Ragno

Abstract


1, 4-dihydropyridine calcium channels blockers (DHPs) are the most commonly used antihypertensive drugs. Unfortunately, these compounds have a significant degradability to light. The oxidation to the pyridine derivative represents the first, and in many cases the only, step of the degradation mechanism. The photodegradation process causes the complete loss of pharmacological activity and may trigger the formation of single and superoxide oxygen species, potentially responsible for phototoxic reactions. Several analytical techniques have been proposed for DHP determination in the presence of their photoproducts. Nowadays, DHPs are all marketed in solid formulations, especially tablets, because photodegradation is particularly fast in solution. Various approaches aimed to protect molecular integrity and therapeutic activity of these drugs from the effects of light are currently studied. This review covers the studies over the last years about photodegradation of the DHPs and the approaches to obtain photostable formulations of these drugs.


Keywords


1, 4-Dihydropyridine drugs, Photodegradation, Phototoxicity, Photostabilization, Stressing test

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About this article

Title

PHOTODEGRADATION OF 1, 4-DIHYDROPYRIDINE ANTIHYPERTENSIVE DRUGS: AN UPDATED REVIEW

Keywords

1, 4-Dihydropyridine drugs, Photodegradation, Phototoxicity, Photostabilization, Stressing test

DOI

10.22159/ijpps.2018v10i1.22562

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 10, Issue 1, 2018 Page: 8-18

Online ISSN

0975-1491

Statistics

55 Views | 91 Downloads

Authors & Affiliations

Michele De Luca
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
Italy

Giuseppina Ioele
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy

Claudia Spatari
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy

Gaetano Ragno
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy


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